Yissum - Research Development Company of the Hebrew University

Anti-Infectious Coating for Dental Implants

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Self-assembly of fluorine-capped moieties for prevention of biofilms
Keywords: self-assembly, dental, dentistry, biolfilm, disruption
Project ID : 9-2015-3142

Yissum - Research Development Company of the Hebrew University

Description of the technology


Life Sciences and Biotechnology, Chemistry & Materials


Dental, Implants, Infection, Biofilm

Current development stage

TRL3 - Hypothesis testing and initial POC is demonstrated in limited number of in-vitro models

Our Innovation

This invention consists of novel and highly improved antifouling materials which spontaneously self-assemble into films and thus promote or encourage adherence of cells.


  • An antifouling agent capable of preventing or arresting adsorption of organic and/or bio-organic materials to a surface and at the same time capable of promoting and encouraging attachment of cells to the surface.
  • Compounds are selected to self-assemble into films.


The physical, chemical and biochemical properties of implant surfaces are some of the most important issues in the design of biomedical devices, as the first interaction between the implant and the body occurs at the interface.

In the case of bacteria, biofouling leads to the formation of a well-defined bacterial network - biofilm. Biofilm formation on medical devices and implants leads to severe infection which may result in patient death.


The materials of the invention are capable of attracting cells from multicellular organisms and preventing antifouling by unicellular organisms. The materials of the invention can be used in biotechnological processes with any eukaryotic cells including mammalian cells or plant cells.


The invention provides a method for preventing, ameliorating, or treating a disease or disorder related to an implant having been placed in a body cavity or on a tissue. The invention provides a method for prolonging the lifetime of an implant and for stimulating or encouraging bone healing or absorption of an implant after implantation.

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Meital Reches
HUJI, Faculty of Science
The Institute of Chemistry

Related keywords

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  • Medicine, Human Health
  • Biology / Biotechnology
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  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
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  • Biochemistry / Biophysics Market
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  • Diagnostic
  • Therapeutic
  • Anatomy, Pathology, Immunology, Physiology
  • Clinical Medicine
  • Chemicals and Materials
  • Life Science & Biotechnology
  • medical device

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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