Summary of the technology
The prototype developed within ERC-PoC "ANTS" project, has demonstrated its sensitivity for a new concept of microcalorimeters, as well as providing advantages in microfluidics.
We aim to:
a) Integrate this technology within microfluidic devices or applications where size and fast response time are crucial.
b) Develop a High-Throughput Calorimetry going beyond the current capabilities on ITC.
> Sensing element. Ferromagnetic permalloy line 4x28 µm x 20 nm thick: affordable, miniaturization… Sensor was fabricated in a single deposition.
> Temporal response. Milliseconds, to stimulus >10 microwatts; further improvements are in progress.
> Easy adoption. Compatible with standard configuration of microcalorimeters.
> IPR: EP, US, CN, KR, JP
Description of the technology
- SPATIAL resolution: due to its tiny size (combined with microdeposition and patterning), it offers a possibility for the integration for microfluidic detectors or other applications where the size and fast response time are crucial.
- TEMPORAL resolution: our tests have already demonstrated a milliseconds response to stimulus of microwatts.
- THERMAL resolution: the thermal voltage generated scales with the length of the line (irrespective of its thickness); thus, a zig-zag configuration will improve its thermal sensitivity still with micron-size resolution.
- Easy adoption: compatible with standard configuration of microcalorimeters.
EXPECTED IMPACT: A novel microcalorimeter with highly improved temporal, spatial and thermal resolution. Thus, ANTS-HTS Calorimeter can be expected to join the ranks of best practices to decrease attrition rates, contributing to reduce the staggering costs of drug development.
Intellectual property status: Patent application number : EP3184981 (A1), US2017268936 (A1), CN107076622 (A), KR20170045252 (A), JP2017532534(A).
Current development status: Laboratory prototypes.