Targets for precision medicine of glioblastoma and other diseases
Cluster8 Genetic and Epigenetic Editing for Brain Tumor Control Project ID : 6-2017-4496
Summary of the technology
Genetic and Epigenetic Editing for Brain Tumor Control
Project ID : 6-2017-4496
Description of the technology
Glioblastoma multiforme, regulatory networks, target genes
Current development stage
TRL3 - hypothesis testing and initial POC demonstrated in-vitro
A novel method to control the activity level of key GBM genes and attack the cancer through its regulatory networks (a new class of genomic targets).
Using a novel mapping technology, a list of critical genomic targets (enhancer sites) for GBM driver genes (unique to our lab and not available for others) were identified in human tumors.
The ability to control glioblastoma proliferation by modifying the regulatory targets via Cas-CRISPR editing was demonstrated.
The activity of the targeted genes was tuned by epigenetic editing of the critical regulatory sites without introducing irreversible genetic modifications