Yissum - Research Development Company of the Hebrew University

Novel, Dual-Action Peptide for Treament of Type 2 Diabetes

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Di-Bait
Project ID : 7-2015-3167

Description of the technology

Category

Life Sciences and Biotechnology

Keywords

Type 2 Diabetes, Peptide, Insulin, Fatty liver, Glucose.

Current development stage

TRL3 Experimental proof of concept

Our Innovation

Based on a provocative working hypothesis, DiBait (DB) has identified the molecular origin of insulin resistance (IR). This, in turn, enables DB designing an 11 a.a. peptide that eliminates IR in animal models.

  • Identification of a structural motif shared by liver key regulatory proteins. IR is induced via post-translational modification (PTM) of these proteins upon starvation and in fatty liver.
  • The designer peptide constitute a decoy of the PTM target-sequence and compete for occupation of the modifying enzyme binding-site, thereby abrogating IR evolvement.

Application

  • Nullifying the vicious circle that starts with peripheral IR, as a result of fatty liver, and ends up as full-blown type-2-diabetes (T2D). In other words, providing a cure to T2D, as opposed to symptomatic treatment.

Pre-Clinical Results

  • Significant, persistent reduction in blood glucose level demonstrated in T2D animal model (db/db mice), following once a day injection of the peptide, observed already after 1 day.
  • This reduction in blood glucose occurs in diabetic but not in normal mice.
  • Significant reduction in plasma triglycerides in treated T2D mice with no effect on terminal plasma insulin or glucagon.

Opportunity

We envision a short peptide or peptidomimetic molecule that is likely to be packaged in a capsule using appropriate formulation for oral administration to cure type 2 diabetes.

The collaboration with major Pharma companies will help accelerate the drug development process and bring an effective therapy to hundreds of millions of T2D patients around the world

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Shmuel Ben-Sasson
HUJI, School of Medicine - IMRIC
Developmental Biology and Cancer Research

Yuval Dor
HUJI, School of Medicine - IMRIC
Developmental Biology and Cancer Research

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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