Yissum - Research Development Company of the Hebrew University

Novel Compounds for the Treatment and Prevention of Autism

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

beta- carotene as treatment for autism
Project ID : 6-2014-3058

Description of the technology

Amnon AlbeckMD- Hadassah Medical School, Hebrew University, Jerusalem

David Mankuta MD - Department of Obstetrics and Gynaecology, Hadassah Hospital

Categories

Prevention &Treatment

Development Stage

In vivo proof of concept; ongoing research

Patent Status

Provisional patent application filed

Market

The prevalence of autism is increasing worldwide and is estimated at between 0.5–2.0% (for autism spectrum disorders (ASDs) it is 1 in 68 children in the United States).

Highlights

·Novel compound administered to the mother during pregnancy or after birth to newborns of families predisposed to "autism" has the potential to prevent /ameliorate autistic symptoms.

·No side Effects in animal models. These results support further clinical studies.

Our Innovation

·A novel compound that can be administered to mothers during pregnancy or after birth of newborns in families predisposed to "autism"– it has the potential to prevent /ameliorate autistic symptoms.

·a safe non-teratogenic natural occurring compound that can be consumed safely by human in vivo and in vitro models, both as a preventive and therapeutic drug in animal models of autism.

·When administered to mice this compound reduces significantly restricted and stereotyped behaviours and interests. Moreover it significantly increased social interactions and communication in offspring.

Development Milestones

Seeking funding for ongoing research and clinical trial.

The Opportunity

An estimated1 in 68 children in the United States develops autism (about 77 million children in USA)

Researcher Information

Yosefa Avraham, PhD,Yosefa@md.huji.ac.il +972-2-6757547.Hebrew University Medical School.

Project manager

Shoshana Keynan
VP, Head of Business Development, Healthcare

Project researchers

Elliot Berry
HUJI, School of Medicine - IMRIC
School of Public Health

Yosefa Avraham
HUJI, School of Medicine - IMRIC
School of Public Health

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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