Yissum - Research Development Company of the Hebrew University

Leptin-Protein Therapy to Improve Nutritional Status, Well-Being, Cognition, and Survival in Nutritionally-Compromised Patients

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

The use of Leptin for treating undesirable manifestations of a nutritional stress condition. The invention shows also a method for improving cognitive function by the use of Leptin
keywords: neurodegenerative
Peptide/Protein

Project ID : 12-2006-576

Description of the technology

Treatment for conditions caused by caloric restrictions and metabolic stress

Categories

Protein Therapy, CNS – Cognition, Nutrition

Development Stage

TRL4 - Proof of concept in animal model

Patent Status

US Patent 189802

Highlights

  • Leptin is an adipokine hormone that plays a central role in food intake, energy balance and body weight regulation
  • Effective in mouse model in improving cognitive functioning and survival rate resulting fromvarious stress states including semi-starvation
  • Application:treatment for weight loss associated with severe malnutrition, gastro-intestinal disorders, malnutrition caused by cancer, HIV, anorexia, and other diseases or injuries affecting nutritional balance

Our Innovation

A pharmaceutical, using leptin for the treatment of undesirable manifestations of nutritional stress conditions. Leptin is used to improve nutritional well-being, metabolic integrity, cognitive function (especially impaired cognition caused by malnutrition), and to prolong survival.

Key Features

  • Strengthens body condition weakened by disease, infection, malnutrition, and other states associated with negative energy balance
  • Administered by injection
  • Already licensed as safe for use in humans (in rare cases of obesity)

The Opportunity

  • Technology offers effective means of improving nutritional status and cognitive functioning caused by malnutrition
  • Treatment modality to prolong survival rate for patients suffering metabolic stress

Researcher Informationhttp://www.hadassah.org.il/English/Eng_SubNavBar/TheDoctors/elliotberry.htm

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Elliot Berry
HUJI, School of Medicine - IMRIC
School of Public Health

Yosefa Avraham
HUJI, School of Medicine - IMRIC
School of Public Health

Sigal Sviri
HUJI, School of Medicine - IMRIC

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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