Creative BioMart

Histone H3-K9 Methylation Assay Kit

Posted by Creative BioMartResponsive · Innovative Products and Technologies · United States

Summary of the technology

Histone H3-K9 Methylation Assay Kit is use for measuring methylation of histone H3-K9.
For specifically measuring histone H3-K9 methylation using a variety of mammalian cells including fresh and frozen tissues, cultured adherent and suspension cells.

Creative BioMart

Description of the technology

Epigenetic activation or inactivation of genes plays a critical role in many important human diseases, especially in cancer. A major mechanism for epigenetic inactivation of the genes is methylation of CpG islands in genome DNA caused by DNA methyltransferases. Histone methyltransferases (HMTs) control or regulate DNA methylation through chromatin-dependent transcription repression or activation. HMTs transfer 1-3 methyl groups from S-adenosyl-L-methionine to the lysine and arginine residues of histone proteins. ESET, G9a, SUV39-h1, SUV39- h2, SETDB1, Dim-5 and Eu-HMTase are histone methyltransferases that catalyze methylation of histone H3 at lysine 9 (H3-K9) in mammalian cells. H3-K9 methylation mediates heterochromatin formation by forming a binding site for HP1 and also participates in silencing gene expression at euchromatic sites. Increased H3-K9 methylation is also found to be involved in some pathological processes such as cancer progress. There are only a couple of methods such as western blot used for measuring histone H3-K9 methylation. These methods available so far are time consuming and labor intensive, or have low throughput. The Histone H3-K9 Methylation Assay Kit addresses theses problems by using a unique procedure to measure methylation of histone H3-K9.

Technology Owner

Creative BioMart

Small and Medium Enterprise

Related keywords

  • Biological Sciences
  • Biology / Biotechnology
  • Genetic Engineering / Molecular Biology
  • Gene Expression, Proteom Research Market
  • Enzymology/Protein Engineering/Fermentation

About Creative BioMart

Small and Medium Enterprise from United States

Creative BioMart is offering more than 1,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.

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