Institute of Chemical Research of Catalonia

Crysforma: services in pharmaceutical solid state development

Posted by Institute of Chemical Research of CataloniaResponsive · Research Services and Capabilities · Spain

Summary of the technology

Crysforma provides complete scientific support for the discovery, analysis and scale-up of polymorphs, hydrates, amorphous phases, salts and co-crystals of active pharmaceutical ingredients or intermediates. Crysforma has developed its own crystallization screening methodology based on the combination of several crystallization procedures. We use high-throughput crystallization systems controlled by highly skilled scientists to maximize the information drawn from each experiment. Our projects are always carried out in close collaboration with the client, adapted to the customer's needs and under strict confidentiality conditions.

Institute of Chemical Research of Catalonia

Description of the technology

Crysforma’s expertise is based on an extensive knowledge and experience in crystallization of small and medium size organic molecules. This expertise is successfully applied to several applications of interest for the pharmaceutical and fine chemicals industry: from polymorphism, salt selection and co-crystal screenings, to the crystallization of compounds that were previously only known as amorphous or as poorly crystalline solids.

Moreover, we have developed our own crystallization screening methodology for each screening type (polymorphism, salt selection and co-crystals), based in the following key points:

  • Crystallization screening methodology adaptable to the API properties and to the company’s needs at each stage of development.
  • Utilization of several crystallization techniques in an optimized group of crystallization solvents.
  • Use of solvent mediated as well as solvent free crystallization procedures.
  • Crystallizations under controlled conditions to facilitate reproducibility and scale-up.
  • Use of high throughput crystallization systems.
  • Crystallizations strictly controlled by highly skilled scientists to maximize the information drawn from each experiment.

We believe that our methodology brings together an optimal compromise in terms of scientific results, costs, timing and API consumption.

Related keywords

  • Organic Chemistry
  • Pharmaceutics
  • Industrial Biotechnology
  • Pharmaceutical Products / Drugs
  • Pharmaceuticals/fine chemicals
  • Food and Beverages
  • Other Medical/Health Related

About Institute of Chemical Research of Catalonia

Technology Transfer Office from Spain

The Institute of Chemical Research of Catalonia represents one of the very first fruits of the new scientific policy of the government of Catalonia (Spain) aimed at creating new research centres in strategic areas. ICIQ, in particular, has been created with the ambition of becoming a reference for chemistry in the European Research Space.

Our society faces important challenges in the XXI century, among which health and environmental concerns are of outmost importance. Chemistry will play an essential role in both of these challenges. To succeed, our increasingly knowledge-based economy will require a solid and strong chemical industry; currently 150.000 jobs in Catalonia (and more than 2 million in the EU) directly arise from the chemical industry. In order for this industry to be successful in the future, it must take a sustainable approach based on the rational use of feed-stocks and raw materials. For this, fundamental chemical research needs to be funded and novel approaches into transforming matter must be developed.

We at ICIQ consider that catalysis is the key activity for sustainable chemistry. Catalytic processes can minimize raw materials and energy consumption, and can lead to the selective formation of target products with minimal generation of wastes. In line with this consideration, we have taken catalysis as one of our main research topics.

Complementary to our research focus, attention has been paid to the development of a simple and efficient organizational model for ICIQ, able to overcome known difficulties normally associated with larger and more traditional research institutions. The Institute of Chemical Research of Catalonia aims at bridging the gap between academic research and industry, focusing its research on catalytic chemical processes for applications in health, energy and sustainability.

At ICIQ, we consider that patents are highly efficient, safe and solid tools to provide protection from competitors. This is why we file patents for our in-house developed-technologies: to give our co-development projects with industry a strong starting IP position. As a research centre our goal is always to co-develop our technology adapting it to the industrial partner’s specific needs and ultimately transfer the technology to this company, with a flexible licensing strategy adapted to each case.

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