Biomedical Imaging in a Portable Unilateral NMR Scanner

The Technology
A diagnostic technique is under development for characterization of skin aging with high resolution deep-skin profiling. The technique is based on existing low-field unilateral NMR scanners.
Mobile unilateral NMR scanners measure NMR parameters (T1, T2, diffusion coefficient, spin density) and facilitate depth profiling of samples with a high resolution (∆Z≈ 20-30 µm). This technology is currently used for non-destructive testing. We are developing a method to use the acquired and derived NMR parameters to characterize specific skin layers, based on their thickness, and their biochemical content. The 1D imaging/profiling data is incorporated into an algorithm which identifies changes in the skin properties that are associated with aging.

The Need
Skin aging is a physiological process affecting all individuals, creating great concern and discomfort for a considerable part of the aging population. There is a need for a non-invasive method for reliable, low-cost depth characterization of the aging skin. Such a method should allow quantification of the 'physiological age' of a skin, and assessment of the temporary or the permanent effect of cosmetic creams or of other cosmetic applications. Such a method, if affordable, could be used by cosmetic clinics as well as by dermatological clinics and labs.

Advantages

• The technology is non-invasive, non-destructive and non-radiation.
• Desktop, single-sided NMR scanners are affordable for small businesses.
• The systems are small, portable and suitable for small labs, offices, clinics and shops.
• The small size and the low magnetic field prevent demanding infrastructure considerations (i.e. no special construction, electric power, magnetic/RF shielding).
• The technique can provide both biochemical and density information.
• The penetration depth covers the entire skin layers and the depth resolution can distinguish between the sub layers of the skin in a scale of a few tens of microns.

Project Status
A Helsinki approval for a dermatological project is in place, approved for collaboration with the dermatological department in RAMBAM Hospital for clinical tests and development.

Supporting Publication and Patent
A provisional patent application submitted.
Bergman E., Yeredor A., Nevo U. "An estimation method of MR signal parameters for improved image reconstruction in unilateral scanner; submitted, pre-publication

Project manager

Rona Samler
VP, BD Physical Science, Medical Device, Chemistry

Project researchers

Uri Nevo
T.A.U Tel Aviv University, Engineering
Bio-Medical Engineering