Laboratory of Immunological and Inflammatory Modules in Malignancy
Innovative Products and Technologies
Technology Offer
Laboratory of Immunological and Inflammatory Modules in Malignancy
- RAMOT at Tel Aviv University Ltd.
- From Israel
- Responsive
- Innovative Products and Technologies
Summary of the technology
Prof. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The research paradigm is integrative, progressing from molecules that promote cancer, through high resolution analyses of tumor cells and animal model systems, to verification of results at the individual patient level.
Project ID : 12-2013-415
Details of the Technology Offer
Research focus
Prof. Ben-Baruch is an immunologist who investigates the roles of immune and inflammatory elements in physiological and pathological conditions, with major emphasis on malignancy. The studies in her laboratory determine the complex regulatory networks established between chemokines and cytokines of the tumor microenvironment, intrinsic oncogenic modifications in tumor cells, and stroma cells. The research paradigm is integrative, progressing from molecules that promote cancer, through high resolution analyses of tumor cells and animal model systems, to verification of results at the individual patient level.
Potential services
I. Consultation services:
Advice can be provided on theoretical and experimental aspects of immunological and inflammatory processes in general, and particularly in malignancy.
II. Laboratory services:
- Setting up murine models of breast cancer, for determination of tumor growth and metastasis: Tumor cell inoculation in hormone-dependent and independent models; Preparation of fluorescently-tagged tumor cells; Use of imaging devices (Maestro, IVIS).
- Motility and migration assays, for determination of cell chemotaxis and chemokinesis: Transwells; Modified Boyden chambers; Scratch assays.
- Cloning of desired cDNAs to vectors.
- Transfection and infection of vectors to established cell lines.
- ELISA, quantitative real-time PCR, Western blotting, Confocal microscopy, e.g. for determination of expression levels of chemokines, cytokines, growth factors and angiogenic factors.
- Flow cytometry and cell sorting, for determination of cell surface and intracellular molecules in cells.
- XTT proliferation assays.
- Immunochemistry staining of biopsy sections of patients.
Contact persons
Prof. Adit Ben-Baruch
Dept. Cell Research and Immunology
George S. Wise Faculty of Life Science
Tel Aviv University
Email:aditbb@tauex.tau.ac.il
Tel: 03-6407933
FAX: 03-6422046
Ms. Tsipi Meshel
Dept. Cell Research and Immunology
George S. Wise Faculty of Life Science
Tel Aviv University
Email:tzipi@post.tau.ac.il
Tel: 03-6409839
FAX: 03-6422046