RAMOT at Tel Aviv University Ltd.

Histopathological evaluation of hard tissues and biomedical devices in their tissue implantation surrounding, using a Plastic Embedding Technique

Posted by RAMOT at Tel Aviv University Ltd.Responsive · Innovative Products and Technologies · Israel

Summary of the technology

Plastic embedding is a method that allows histological examination of soft and hard tissues (e.g., blood vessels, bones, teeth, joints and skin tissue), containing solid medical devices of different sizes and made of various materials. In addition to the standard histological observations, such as necrosis, inflammation and fibrosis, this technique provides reliable data on size and shape of anatomical structures, such as blood vessels’ diameter or tissue proliferation adjacent to the implant.
In order to perform plastic embedding, it is not necessary to remove the biomedical device from the tissue. Therefore, this technique is ideal for the examination of tissue-implant interaction. Furthermore, the use of diamond saws enables us to cut through extremely hard materials. For example, we can successfully create histological slides even from titanium-based implants.
In the frame of our histological services using the plastic embedding technique, we offer our clients the opportunity to examine the pathological changes and tissue reactions to an implanted medical device, a goal that cannot be adequately achieved using other techniques, such as the paraffin embedding technique.

Project ID : 12-2012-360

Description of the technology

Plastic embedding is a method that allows histological examination of soft and hard tissues (e.g., blood vessels, bones, teeth, joints and skin tissue), containing solid medical devices of different sizes and made of various materials. In addition to the standard histological observations, such as necrosis, inflammation and fibrosis, this technique provides reliable data on size and shape of anatomical structures, such as blood vessels’ diameter or tissue proliferation adjacent to the implant.

In order to perform plastic embedding, it is not necessary to remove the biomedical device from the tissue. Therefore, this technique is ideal for the examination of tissue-implant interaction. Furthermore, the use of diamond saws enables us to cut through extremely hard materials. For example, we can successfully create histological slides even from titanium-based implants.

In the frame of our histological services using the plastic embedding technique, we offer our clients the opportunity to examine the pathological changes and tissue reactions to an implanted medical device, a goal that cannot be adequately achieved using other techniques, such as the paraffin embedding technique.

Contact:
Prof. Israel Hershkovitz
Department of Anatomy and Anthropology
Sackler School of Medicine
Tel-Aviv University
Telephone: +972-3-6409495
Fax: +972-3-6407306
Email:
anatom2@post.tau.ac.il

Project manager

avi Wener
Research services

Project researchers

Israel Hershkovitz
T.A.U Tel Aviv University, Medicine-Sackler Faculty
Anathomy and Anthropology

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About RAMOT at Tel Aviv University Ltd.

Technology Transfer Office from Israel

Ramot is Tel Aviv University's (TAU) technology transfer company and its liaison to industry, bringing promising scientific discoveries made at

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