Centre Technology Transfer CITTRU

Plant-based preparations in the treatment of nosemosis in honeybees and an increase their immunity

Posted by Centre Technology Transfer CITTRUResponsive · Patents for licensing · Poland

Summary of the technology

The subject of the offer are plant-based preparations and their use in the treatment of nosemosis. The invention uses plants which improve immunity and impact on the longevity of bees. The preparations provide an alternative to commonly used drug in the treatment of nosemosis.

New and innovative aspects

Nosemosis, caused by Nosema spp., is a global phenomenon. Nosemosis is a panzootic bee disease caused by two species of the genus Nosema (Fungi: Microsporidia): Nosema apis and Nosema ceranae. In the last decade there has been rapid development and spread of bee diseases, creating serious problems for bee keeping management. There are a lot of factors which cause this disease, such as parasites, bacterial and fungal diseases, genetic disorders, inappropriate nutrition and use of pesticides. Nosema spp. spores are extremely resistant to external stress factors and can survive several years without losing their ability for further infection within an insect body. For this reason combating nosemosis is difficult. Until now no effective cure for nosemosis has been discovered that would be harmless to bees and not contaminate honey. Some beekeepers add ethanol to the sucrose solution before the winter to prevent nosemosis infection and to cure already infested colonies. But disease prevention mainly relies on a respecting the principles of hygienic breeding. As far, in the treatment of nosemosis  fumagillin was used. However, because of a large number of side effects, use of this antibiotic has been forbidden in the European Union. In addition to this, Nosema pathogens have developed a resistance to this drug. Another problem in use of fumagillin was its poor solubility in sugar syrup and a need to use  co-solvent, which resulted in a detection of the fumagillin metabolites in honey.There have been trials to use other plant-based products (extract of Oak bark) but their action is not sufficiently effective.On the basis of an empirical use, it is evidence that currently used  methods have not been effective in the treatment of bees’ nosemosis.The subject of the offer  uses plants which improve immunity and impact on the longevity of bees. The preparations provide an alternative to commonly used drug in the treatment of nosemosis. 

Main advantages of its use

  • plant-based constituents
  • high effectiveness in the nosemosis treatment (Nosema apis and Nosema ceranae).
  • improvement of bees’ immunity, expressed as an increase of phenolic oxidase activity (enzyme taking part in the immune response)
  • lack of side effects


The offered invention relates to a new plant-based preparation which may be used in the treatment of nosemosis.


In the treatment of bees’ diseases by an increase of immunity

Intellectual property status

Plant-based preparations, which may be used in the treatment of nosemosis in bees and to increase their immunity, are the subject of patent applications in Poland. Priority date for the invention is December 2015 with PCT patent application deadline in December 2016.

Current development status

Proof of concept has been completed. Further research and development of the invention are continued at the Marie Curie-Skłodowska University in Lublin, University of Life Sciences in Lublin, and Jagiellonian University in Cracow.

Desired business relationship

Currently the Centre for Technology Transfer CITTRU is looking for entities interested in:

  • licensing and
  • commercial application of the described solution

Related keywords

  • Veterinary Medicine
  • Crop Production
  • Biocontrol
  • Agriculture
  • Animal health
  • Agro and Marine biotech
  • Plant and animal health
  • treatment of nosemosis
  • honeybees
  • improvement of bees’ immunity

About Centre Technology Transfer CITTRU

Technology Transfer Office from Poland

Centre for Innovation, Technology Transfer and University Development (CITTRU) is a part of Jagiellonian University, whose role is to promote university research, to support innovation and to create cooperation with the business. CITTRU main task is to offer the scientific achievements of the Jagiellonian University in the market by providing legal protection, licensing, sale of intellectual property rights, creation of academic business, coordination of company-ordered research projects, etc. Currently promoted technologies are mainly focused on new materials science, pharmacology and medical technology. Inventions offered by Jagiellonian University are promoted and awarded during numerous exhibitions, e.g. 58th International Exhibition of Innovation, Research and New Technologies INNOVA (BRUSSELS 2009), 38th International Exhibition of Invention New Techniques & Products (Geneva 2010) or 24th International exhibition of environmental equipment, technologies and services POLLUTEC (Paris 2009).

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