Summary of the technology
The present invention provides novel biocompatible “core-shell” systems and the surfactant-free method of their preparation using macromolecular compounds. Biocompatible nanocapsules with liquid cores which enable effective encapsulation of hydrophobic compounds are stabilized without low molecular weight surfactants. These beneficial features significantly increase the range of possible applications.
New and innovative aspects
Stable and biodegradable oil in water (O/W) nanoemulsions are one of the most common types of nanoformulations used for delivery and release of hydrophobic compounds, particularly biologically active substances (such as drugs, vitamins, hormones, pigments, antioxidants, pesticides, contrast agents for magnetic resonance imaging or positron emission tomography). The main goal of such carriers is to improve performance of the encapsulated compounds through their protection against degradation, reduction of toxicity by decreasing the adverse effects of body tissues and/or increasing the bioavailability of such sparingly water-soluble substances. Due to the thermodynamic instability of nanoemulsions, it is a great challenge to obtain stable droplets. Hence, surface-active agents (surfactants) are commonly used to stabilize oil droplets as they are able to adsorb at the water/oil interface leading to the reduction of the surface tension. It causes a disruption of the droplet surface, reduction of their sizes and prevents their aggregation due to repulsive electrostatic forces. Nevertheless, dilution of such suspensions results in removal of the surfactants from the interface and uncontrolled release of encapsulated compound before reaching the target what is highly unfavorable from the application point of view.
For biomedical applications or food industry it is important to minimize the number of components of such system, as any additive can interact with tissues and cause the adverse side effects.The subjects of this offer are biocompatible submicrometric capsules templated on liquid cores that enable effective encapsulation of lipophilic compounds.
Main advantages of its use
- resistance to changes of environmental parameters (pH or concentration)
- wide range of applications, for example as carriers of lipophilic compounds of low bioavailability or nanoreactors in enzymatic and/or biological processes
- reduced risk of damage of active compounds and enhanced loading capacity as a result of direct encapsulation during of the process of preparation of the capsules
- simplicity of the manufacturing process
- low energy and financial investment in the production process
The present invention provides novel biocompatible “core-shell” systems and the surfactant-free method of their preparation using macromolecular compounds. Biocompatible nanocapsules with liquid cores which enable effective encapsulation of hydrophobic compounds are stabilized without low molecular weight surfactants.
Carriers for hydrophobic active compounds (e.g. drugs, dietary supplements) in an aqueous medium - biomedical, pharmaceutical, cosmetic and food industries
Intellectual property status
Nanocapsules for delivery of lipophilic compounds and method of their preparation are the subjects of patent application in Poland. PCT patent application is expected in July 2016 (priority date July 2015)
Current development status
Proof of concept has been completed. The invention is still tested by the scientists from Faculty of Chemistry of the Jagiellonian University.
Desired business relationship
Currently the Center for Technology Transfer CITTRU is looking for entities interested in commercial application of describe innovation: licencing and/or collaboration with scientists from Faculty of Chemistry (further development, testing of new applications, adaptation to specific needs).
About Centre Technology Transfer CITTRU
Technology Transfer Office from PolandCentre Technology Transfer CITTRU
Centre for Innovation, Technology Transfer and University Development (CITTRU) is a part of Jagiellonian University, whose role is to promote university research, to support innovation and to create cooperation with the business. CITTRU main task is to offer the scientific achievements of the Jagiellonian University in the market by providing legal protection, licensing, sale of intellectual property rights, creation of academic business, coordination of company-ordered research projects, etc. Currently promoted technologies are mainly focused on new materials science, pharmacology and medical technology.
Inventions offered by Jagiellonian University are promoted and awarded during numerous exhibitions, e.g. 58th International Exhibition of Innovation, Research and New Technologies INNOVA (BRUSSELS 2009), 38th International Exhibition of Invention New Techniques & Products (Geneva 2010) or 24th International exhibition of environmental equipment, technologies and services POLLUTEC (Paris 2009).