Short Peptides Derived from GPCR that Selectively Modulate Signal Transduction for Vascular Disorders (Pro Angiogenic Molecules)
Cardiovascular, Peptide / Protein Project ID : 7-2006-574
Summary of the technology
Cardiovascular, Peptide / Protein
Project ID : 7-2006-574
Description of the technology
Life Sciences and Bio Technology
One of the largest families of receptors in the human genome is that of the 7 transmembrane receptor (7-TMR) superfamily, also known as G-protein coupled receptors (GPCRs), numbering approximately 2000.
G-protein coupled receptors regulate a large number of important physiological processes. At least 40% of the prescription drugs that have been developed have actions related to these receptors. Most of these drugs work by interfering with the ligand binding to the receptor that occurs outside of cells. G-proteins are important effectors of cell activation
The current technology is based on the discovery that compounds, comprising relatively short sequences of 5 to 20 amino acids, identical to native sequences appearing in a specific region of any of the 2nd loop of 7 transmembrane receptor are capable of altering the signal transduction mediated by the same 7TM receptor from which the sequences were obtained.