Yissum - Research Development Company of the Hebrew University

Novel, On Demand, RF-Triggered, Degradable Implants (IVC Filters)

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

An innovative scientific and technological multidisciplinary approach to solve a central problem in medicine, VTE, that directly endangers the
lives of many patients at risk.?To overcome the limitation of degradable and non-degradable filters, we now introduce a novel concept in implant design which will be first applied to construct IVC filters. We propose to develop an “on demand” degradable implant which can be rapidly dissolved in vivo in response to external stimuli like an electro-magnetic field and after verifying by imaging that there are no trapped clots in the IVC filter. we aim to address two of the most critical problems in biomedicine: one is the precise device life span and the other is simple and immediate destruction of
mal- positioned devices and implants in-vivo with minimal adverse side-effects and maximal clinical benefit to patients.

Old Title: Novel, On Demand, RF-Triggered, Degradable Implants
Project ID : 7-2015-3084

Yissum - Research Development Company of the Hebrew University

Description of the technology

Category

LifeSciences and BioTechnology

Keywords

Implant, Medical Devices, Biodegradable, BioTech

Current development stage

TRL3 Experimental proof of concept

Application

  • Implant devices are extensively used, but have a few limitations:
  • Most implants remain in the body even after they finish their mission
  • Removal of implants is costly and requires an invasive procedure; only 20-30% are actually removed
  • Biodegraded implant have a pre-determined life span which may not correlate with the healing process and the medical need
  • FDA safety alert in Feb. 2011: ” Filters should be removed if possible”

Our Innovation

A novel concept in implant design which will be first applied to construct IVC filters - an “on demand” degradable implant which can be rapidly dissolved in vivo in response to external stimuli like an electro-magnetic field and after verifying by imaging that there are no trapped clots in the IVC filter.

Advantages

  • Flexibility - custom made fibers with predesigned strength, elasticity, heat capacity, and diameter
  • Novelty – a new concept of RF-triggered fiber
  • Platform technology - can be used for different implants
  • Safety - biocompatible materials, no special regulatory issues are expected, non-invasive removal
  • Manufacturing - using existing methods of fabrication: coaxial extrusion and Texturing
  • Cost - inexpensive product and fewer procedures

Technology

The researchers aim to address two of the most critical problems in biomedicine: one is the precise device life span and the other is simple and immediate destruction of mal- positioned devices and implants in-vivo with minimal adverse side-effects and maximal clinical benefit to patients.

The new procedure has two steps: filter implantation and develop a non-invasive Radio Frequency (RF) induction.

Once radio frequencies are on, iron oxide nanoparticles produce heat

Once hot, PCL/PLA will melt down for a quick core dissolution

The filter shape disintegrates within seconds

All products are biodegradable and safe.

Opportunity

  • IVC Filters are a unique example of a much needed degradable "on demand" Device
  • IVC filter is a medical device that is implanted into the Inferior Vena Cava to prevent life-threatening pulmonary emboli
  • One filter costs 1000$ + 10,000$ Procedure
  • Estimated annual use of 250,000 filters in the USA alone (2012) (250,000 more world-wide), half for prophylactic indications.
  • FDA approved retrievable filters in 2003

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Danny Porath
HUJI, Faculty of Science
The Institute of Chemistry

Oded Shoseyov
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Plant Sciences and Genetics

Ofra Benny
HUJI, School of Medicine - IMRIC
School of Pharmacy- Institute for Drug Research

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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