New developed hydrogel dressing shield, biocompatible, biodegradable and bioactive, with an appropriate viscosity and adhesion capacity, easy to apply with the endoscope, to treat mucosal lesions in the gastrointestinal tract.
Background
Colonoscopic procedures have become an standard practice worldwide since colorectal cancer and inflammatory bowel disease are becoming prevalent disorders. These techniques have true advantages over surgery but can induce adverse events as bleeding, perforation and coagulation syndrome. Several approaches for avoiding the post-operative complications have been described.
Our results up to day
The proposed product is a hydrogel with bioactive, biodegradable, and bioadhesive properties that can be administered through the endoscope working channel, directly on the mucosal lesions. This composition can easily and rapidly be applied without requiring any special or complex devices. Due to its viscosity and adhesion properties at body temperature, has the ability to remain adhered to the affected area for a long period of time, facilitating the physiological healing of the lesion promoting the mucosal reepetelization instead. This hydrogel has been tested in preclinical studies of rat and porcine models of colon microperforation, showing strong healing properties and avoiding mortality and reducing the risk of peritonitis development. Mucosal healing rate (percentage of mucosal restoration) and physiological healing (absence of submucosal fibrosis) were significantly higher in animals treated with our hydrogel.
Advantages
•This technique is easy to apply and cost/effective
•The use of this composition would minimize the morbidity and mortality associated with therapeutic endoscopy
•This composition promotes mucosal reepitelization instead of cicatrization
Intellectual property status
PCT Patent Application
Product Profile
CATEGORY | TARGET PRODUCT PROFILE |
Clinical Indication | To treat/prevent mucosal lesions or skin ulcers |
Thermal injury associated/caused by therapeutic endoscopy (Coagulation syndrome) | |
Adjuvant therapy to mechanical treatments in gastrointestinal perforations. | |
Sealant treatment in surgical anastomoses and leaks or fistulas in gastrointestinal tract. | |
Safety | Composition is biocompatible and biodegradable. |
Physical Characteristics | Composition shows suitable viscosity and adhesion properties. At body temperature, it has the consistency of a gel, and has the ability to remain adhered to the affected area. |
Desired business relationship
• Licensing Out
• Co-development
Additional information (attached documents)
MISSIONS
The mission of the Health Sciences Research Institute of the “Germans Trias i Pujol” Foundation (IGTP) are to generate, preserve, disseminate and increase multidisciplinary and translational knowledge, as well as echnological development in biomedical sciences, by means of a dynamic, efficient and effective organisation.
GOALS
The ultimate goal of the IGTP is to become a research centre of reference, able to transfer the generated knowledge into clinical practice and therapeutics (translationality), in order to optimise the psychophysical health and quality of life of the population.
VISION
- The IGTP, as an institution devoted to biomedical research:
- Assumes its humanitarian view, ethical principles, and solidarity, as well as the principles of sustainability in resource management and relationship with the environment.
- Its activities will be always related with the health needs of the population and the priority areas in healthcare development.
- Assumes the scientific method as its own and faces its goals by means of programs of excellence which enable the leadership in the areas of knowledge of the interest of its researchers.
- Protects the data used in, and generated by the research programmes, as well as the privacy of the patients and healthy individuals who participate in them.
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