DIT Hothouse

Bcc Vac: A Bcc Cystic Fibrosis Vaccine

Posted by DIT HothouseResponsive · Knowhow and Research output · Ireland

Summary of the technology

A new vaccine to protect cystic fibrosis and other vulnerable patients against Burkholderia cepacia complex (Bcc),a highly antibiotic resistant pathogen that invades the lung epithelium and escapes beyond the lung.

DIT Hothouse

New and innovative aspects

Researchers from Institute of Technology Tallaght have developed a new vaccine to protect cystic fibrosis and other vulnerable patients against Burkholderia cepacia complex (Bcc),a highly antibiotic resistant pathogen that invades the lung epithelium and escapes beyond the lung. 

Main advantages of its use

Novel Solution: This innovation addresses an unmet clinical need as there are currently no available prophylactic vaccines for Bcc nor are there any vaccines currently in human trials. Therapeutic options are also limited and of low efficacy.

• A Prophylactic Vaccine against lung infections in people with Cystic Fibrosis Bcc Vac Life Science Reduced Healthcare Costs: Bcc Vac should prevent patients, healthcare providers and insurance companies from incurring the considerable costs associated with repeated hospitalisation and expensive high dose antibiotics for a patient colonised with Bcc. 

Patient Safety: Antimicrobial resistance, potential kidney damage and hearing loss following long term antibiotic treatment can further impair patient quality of life, in addition to the added costs of treating these healthcare issues. Vaccination is a safer alternative for patients.

Effectiveness: Bcc Vac should be more effective than current approaches that rely on high doses of antibiotics to combat infections. Such approaches are ineffective as Bcc is highly resistant to antibiotics and has the ability to utilise certain antibiotics as a nutrient source.  

Specifications

We are seeking a commercial partner within the healthcare or biopharmaceutical sector to optimise the manufacturing and purification process of the Bcc vaccine and take it to market. The Bcc pathogen is causing increasing concern beyond CF sufferers giving it strong use potential amongst other patients and species. It is envisaged that patients, government health departments and health insurance companies will pay for the vaccine. The vaccine market in general is growing due to the intense use of antibiotocs resulting in a growing resistance to antibiotic treatment. The development of new vaccines is a promising solution to these issues for a wide range of infectious diseases. We offer flexible commercial terms to licensees on technologies developed through ITTD research.

Applications

The vaccine aims to protect people with Cystic Fibrosis, chronic granulomatous disease patients and other vulnerable populations. This pathogen is causing increasing concern beyond CF patients. The vaccination could also be a potential treatment for Glanders, a closely related infectious disease contracted primarily by horses, mules and donkeys through ingestion of contaminated food or water.

Intellectual property status

To protect the intellectual property associated with this technology, a patent has been filed with the European patent office.

Current development status

The two antigens comprising BccVac have been tested in mice and demonstrated excellent efficacy as protective vaccines against Bcc when mice were subsequently challenged with the bacteria. The project has received support and validation from a clinical, technical and commercial perspective. This innovation is patent-pending. 

Desired business relationship

The project team at the Centre of Microbial Host Interactions has been studying the interactions between the bacteria and human lung cells since 2003 in an effort to develop novel therapeutics to eliminate infections in vulnerable hosts. The group focuses on pathogens which cause chronic infection in cystic fibrosis (CF) patients. CF is a genetic recessive disorder resulting in poor clearance of bacteria from the airways. Chronic opportunistic infections in these patients contribute to lung function decline. The infections are caused by a range of bacterial pathogens each with their own virulence features and all highly resistant to antimicrobial therapy. The Principal Investigators in the Centre of Microbial Host Interactions are Dr Siobhán McClean, Dr Máire Callaghan and Dr Emma Caraher. The team includes eight PhD students and a post doctoral researcher. Dr McClean developed Bcc Vac together with a PhD student, Minu Shinoy. Dr McClean has 20 years post-doctoral research experience. She spent five years in the Pharmaceutical industry prior to joining ITT Dublin, where she worked on oral drug delivery and vaccine development projects. Dr Karen English, NUI Maynooth, is a key collaborator in the future development of the Bcc Vac project. Dr English has considerable experience in developing vaccination models against respiratory infections. 

More Information

Click here to download the Bcc Vac Technology Information Sheet

Related keywords

  • Diagnostics, Diagnosis
  • Gene - DNA Therapy
  • Medical Technology / Biomedical Engineering
  • Virus, Virology / Antibiotics / Bacteriology
  • Human vaccines
  • Cellular and Molecular Biology Technology
  • Pharmaceutical Products / Drugs
  • Genetic Engineering / Molecular Biology
  • Therapeutic
  • Other medical/health related (not elsewhere classified)
  • Emergency medicine Market
  • Anatomy, Pathology, Immunology, Physiology
  • connected health & independent livin diagnostics
  • medical devices
  • cystic fibrosis
  • bcc
  • vaccines
  • prophylactic vaccine
  • kidney/lung injuy

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Technology Transfer Office from Ireland

DIT Hothouse is the award-winning Innovation and Knowledge Transfer Office at Dublin Institute of Technology, responsible for the commercialisation of intellectual property arising from DIT research. DIT Hothouse is the hub of innovation and technology transfer activities in DIT, the place where business meets innovation. DIT Hothouse has a range of spinout technologies available to industry across Life Sciences, Food, ICT, Software, Industrial Technology, Manufacturing and Clean Technologies. Our team works with students, lecturers and research teams across DIT as well as with entrepreneurs, industry leaders and investors. Through the DIT Hothouse New Frontiers Startup Programme, we provide a startup incubator for innovative and promising startup companies.

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