Summary of the technology
This novel computerized method will assist physicians in diagnosis, in prediction of clinical outcomes and possibly in formulating therapeutic approaches for treating a wide variety of cancers. The method is a general one and can successfully work for any disease type if an adequate size sample of microarrays is provided
PATENT WAS ABANDONED, commercialization possible based on implied know-how only.
Project ID : 19-2006-164
Description of the technology
Genomic big data analysis enabling better diagnostics and therapeutic approach
Oncology software, cancer diagnostics, personalized medicine
TRL 5Validated in relevant operation environment
U.S. patent 8,423,296,2013
- Current cancer diagnostic` methods rely on descriptive histopathological data.
- New technology measures patient genomic data against detailed classification of cancer types from databases of measured tumour genomic expression profiles
- The method monitors genetic changes enabling improved accuracy of diagnosis
- Since molecular changes often precede morphological changes, genetic assessment of cancer patients may be used for early detection of the disease.
This new tool measures the similarity between gene data derived from DNA gene tests (microarray, deep sequencing, nanostring ..) of a patients malignant tissue with sets of gene test data from pre-classified malignancies. The actual similarity distance obtained provides a powerful and sensitive diagnostic tool for each patient.
- Increased diagnostic and detection accuracy, reclassification into new subgroups. A clear similarity value to different clinical states.
- Enables cancer diagnosis, prediction of clinical outcomes and formulation of therapeutic approach
- General method may be used for any type of disease if an adequate size sample of microarrays from previously classified disease is available
Seeking industry cooperation for further development with companies that can prepare datasets
25 million people in Japan, Europe and North America have cancer; 10.1 million additional cases diagnosed worldwide each year. By 2020, that number will grow to 15 million new cases annually. (World Health Organization)