Yissum - Research Development Company of the Hebrew University

Biocompatible Adhesive with Improved Adhesion

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Research Services and Capabilities · Israel

Summary of the technology

Pressure-sensitive adhesives (PSAs) are adhesives that are capable of bonding to surfaces when light pressure is briefly applied. PSA's are used for medicinal patches, medical devices, tapes, dressings and bioelectrodes. PSAs must provide adequate skin adhesion and cohesion; biocompatibility (be biologically inert to preclude contact dermatitis, allergy, sensitivity or toxicity; repositioning ability on the skin surface for multiple applications; small geometric dimensions; reasonable cost; and compliance with international pharmaceutical standards.
Keywords: bandages
Project ID : 6-2006-40

Description of the technology

Patches derived from tree gum exudate stick to skin better

Categories

Chemistry & Materials, Adhesives, Life Science & Biotechnology , Drug delivery

Development Stage

Developing variety of adhesive materials with controlled composition and adhesiveness

IP Status

Scientific expertise - Know-How

Highlights

  • Adhesive skin patches are used for a wide variety of purposes.
  • Their main disadvantages are that they may be too adhesive (difficult to remove, not adhesive enough and fall off without being noticed (contraceptive patches), and they can cause irritation.
  • If they are too adhesive, residues may be left on the skin after removal.
  • New proprietary adhesive has improved material-skin adhesion and biocompatibility.

Our Innovation

Adhesive materials based on chemically and physically modified polysaccharides which are partially depolymerised to provide more effective adherence to a substrate. These are the first totally natural adhesives made from various tree exudates. At least three such exudates were found to work well.

Key Features

  • The adhesives can be applied under different pH conditions.
  • After the adhesive is removed, no remains are left on the skin, providing a good solution for both drug delivery and for other ingredients, such as essential oils, and for cosmetic purposes.
  • Improved control of composition, adhesiveness, and elasticity
  • The adhesive materials accommodate themselves to the skin structure and improved compatibility is achieved due to creeping of the material into skin crevices. The improved surface contact leads to better adhesiveness and better drug delivery.
  • High manufacturability, entailing flexible pricing strategy
  • All exudates from the same, or a botanically similar, family are generally recognized as safe (GRAS) and are FDA approved

Development Milestones

Seeking funding for ongoing work and industrial collaboration.

The Opportunity

  • Transdermal patches are used for drug delivery and treatment against warts by diffusion of salicylic acid from the patch, as well as cessation of smoking and contraception
  • Non-medicated uses include thermal and cold patches, weight loss patches, nutrient patches, skin care patches (therapeutic and cosmetic), aroma patches, patches that measure sunlight exposure, and aromatherapy by inclusion of essential oils into the adhesive materials
  • Wound treatment
  • Improved adhesive patches for ECG and other procedures
  • Attachment of microelectronics for medical sensing, computer gaming, and surveillance operations

Project manager

Amichai Baron
VP, Head of Business Development, Agritech & Envir

Project researchers

Amos Nussinovitch
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Biochemistry, Food Science and Nutrition

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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