Yissum - Research Development Company of the Hebrew University

Novel Peptides for the Control of Reproduction in Fish

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Novel Peptides for the Control of Reproduction in Fish
Project ID : 24-2011-2633

Description of the technology

Enables hormonal manipulation of the reproductive cycle


Agriculture, Aquaculture, Fish Culture, Animal Sciences, Mariculture

Development Stage

Preliminary proof of concept; ongoing research

Patent Status

United States patent application filed.


  • The endocrine regulation of vertebrate reproduction is achieved by the coordinated actions of several peptide neurohormones.

  • With fish being an important food source, there is a need to better understand how to increase their reproductive capabilities.

  • However, in fish, it was found that the same genes did not appear to be directly involved in the initiation of the reproductive cycle as was shown for mammals.

Our Innovation

Following the identification of Neurokinin B (NKB) genes in fish, we developed analogs that enable manipulation of hormonal activity and reproductive cycles. Antagonists will enable the inhibition of reproduction of farmed fish.

Key Features

  • The new analogs will help to obtain successful spawning and improved egg quality in farmed fish, especially of fish species that are late-maturing.

  • The new antagonists will help to prevent early sexual maturation of farmed fish that ends up in small size cultured fish.

  • Simple and low cost method

  • Unlike other agents that are in the market, the new agent will enable the control of different stages of fish reproduction.

  • The novel agents will be appropriate for both males and females.

  • These analogs will fit different species of fish.

Development Milestones

  • Seeking an industrial partner to commercial this technology and further funding of research.

The Opportunity

  • The method (inject fish with hormones) been used today is expensive.

  • This novel agent will be able to either facilitate or halt fish reproduction.

  • Can fit many fish species, at different stages.

Project manager

Amichai Baron
VP, Head of Business Development, Agritech & Envir

Project researchers

Chaim Gilon
HUJI, Faculty of Science
The Institute of Chemistry

Berta Levavi-Sivan
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Animal Sciences

Related keywords

  • Agriculture
  • Agro chemicals
  • Veterinary Medicine
  • Agriculture, Forestry, Fishing, Animal Husbandry and Related Products
  • Agricultural genetic engineering applications
  • Agricultural chemicals
  • Animal health
  • agriculture
  • aquaculture

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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