Summary of the technology
Research & Services | Mitochondrial Research
Project ID : 34-2010-2527
Description of the technology
Department of Microbiology and Molecular Genetics, Faculty of Medicine,
Research Hub Goals and Activities
To develop collaborations with industry bodies to further the understanding of mitochondrial metabolic diseases in humans, the mechanisms of cancer propagation and mitochondrial dysfunction, mitochondrial dysfunction in Parkinson disease, and more, in order to develop diagnostics and treatments
Assembly of joint mitochondrial related proteomic and genomic databases and web sites specifying detailed mitochondrial experimental approaches Incorporation of new imaging based techniques such as the FRET-based imaging that enables tracking of dynamic interactions within the cellular environment
Acquisition of shared scientific equipment for mitochondrial research
Organization of joint conferences and workshops To extend advancements in these fields to the public sector
Mitochondria are organelles of eukaryotic organisms that are not only essential for respiration but are also essential for supplying precursors of central metabolism.
Mitochondria also play a pivotal role of in the processes such as programmed cell death during normal development, as well as in propagation of diseases.
Medical research has discovered numerous interfaces with mitochondrial function revealing the basis for diseases such as deafness, blindness, diabetes, cancer, premature aging, muscular dystrophy, neurological (including Parkinson and peripheral neuropathies), and multi-system disorders.
Research areas include oxidative stress, organelle evolution, aging, apoptosis, organelle biogenesis, protein import, membrane synthesis, and the mitochondrial genetic system (translation, transcription and DNA replication).
Studies will be conducted by physicians, molecular and cell biologists, biochemists, and physiologists.
Hub Members and Focus
Orly Elpeleg: Genetics of mitochondrial metabolic diseases in humans
Hovav Nechushtan: Mechanisms of cancer propagation and mitochondrial dysfunction
Ophry Pines: Mitochondrial protein dual targeting in eukaryotes and Mitochondrial protein targeting and function in human disease
Joseph Shlomai: Replication of human mitochondrial DNA
Haya Lorberboum-Galski: Protein replacement therapy for mitochondrial disorders
Ronit Sharon: Mitochondrial dysfunction in Parkinson disease models
Industry Collaboration Projects:
Production of organic acids by yeast
Apoptosis-inducing chimeric proteins for targeted human therapy
Apoptosis-inducing chimeric proteins for targeted cancer therapy.
Identification of molecules that regulate α-Synuclein oligomerization in Parkinson’s disease.
VP, Head of Research Collaborations
HUJI, Faculty of Medicine
About Yissum - Research Development Company of the Hebrew University
Technology Transfer Office from IsraelYissum - Research Development Company of the Hebrew University
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.