Yissum - Research Development Company of the Hebrew University

Research & Services | Mitochondrial Research

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Research Services and Capabilities · Israel

Summary of the technology

Research & Services | Mitochondrial Research
Project ID : 34-2010-2527

Description of the technology

Department of Microbiology and Molecular Genetics, Faculty of Medicine,

ophryp@ekmd.huji.ac.il

, 972-2-675-7203

IMRIC

Institute for Medical Research Israel-Canada

Research Hub Goals and Activities

  • To develop collaborations with industry bodies to further the understanding of mitochondrial metabolic diseases in humans, the mechanisms of cancer propagation and mitochondrial dysfunction, mitochondrial dysfunction in Parkinson disease, and more, in order to develop diagnostics and treatments

  • Assembly of joint mitochondrial related proteomic and genomic databases and web sites specifying detailed mitochondrial experimental approaches Incorporation of new imaging based techniques such as the FRET-based imaging that enables tracking of dynamic interactions within the cellular environment

  • Acquisition of shared scientific equipment for mitochondrial research

  • Organization of joint conferences and workshops To extend advancements in these fields to the public sector

Scientific Background

  • Mitochondria are organelles of eukaryotic organisms that are not only essential for respiration but are also essential for supplying precursors of central metabolism.

  • Mitochondria also play a pivotal role of in the processes such as programmed cell death during normal development, as well as in propagation of diseases.

  • Medical research has discovered numerous interfaces with mitochondrial function revealing the basis for diseases such as deafness, blindness, diabetes, cancer, premature aging, muscular dystrophy, neurological (including Parkinson and peripheral neuropathies), and multi-system disorders.

  • Research areas include oxidative stress, organelle evolution, aging, apoptosis, organelle biogenesis, protein import, membrane synthesis, and the mitochondrial genetic system (translation, transcription and DNA replication).

  • Studies will be conducted by physicians, molecular and cell biologists, biochemists, and physiologists.

Hub Members and Focus

  • Orly Elpeleg: Genetics of mitochondrial metabolic diseases in humans

  • Hovav Nechushtan: Mechanisms of cancer propagation and mitochondrial dysfunction

  • Ophry Pines: Mitochondrial protein dual targeting in eukaryotes and Mitochondrial protein targeting and function in human disease

  • Joseph Shlomai: Replication of human mitochondrial DNA

  • Haya Lorberboum-Galski: Protein replacement therapy for mitochondrial disorders

  • Ronit Sharon: Mitochondrial dysfunction in Parkinson disease models

Industry Collaboration Projects:

  • Production of organic acids by yeast

  • Apoptosis-inducing chimeric proteins for targeted human therapy

  • Apoptosis-inducing chimeric proteins for targeted cancer therapy.

  • Identification of molecules that regulate α-Synuclein oligomerization in Parkinson’s disease.

Project manager

Itzik Goldwaser
VP, Head of Research Collaborations

Project researchers

Ophry Pines
HUJI, Faculty of Medicine

Related keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Clean Industrial Technologies
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Clinical Medicine
  • Anatomy, Pathology, Immunology, Physiology
  • Agro and Marine biotech
  • Other Medical/Health Related
  • Therapeutic
  • Diagnostic
  • Other (uncategorised)
  • Life Science & Biotechnology
  • cns

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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