Yissum - Research Development Company of the Hebrew University

Research & Services | Molecular Modeling and In Silico Drug Design

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Research Services and Capabilities · Israel

Summary of the technology

Research & Services | Molecular Modeling and In Silico Drug Design
Project ID : 34-2010-2358

Yissum - Research Development Company of the Hebrew University

Description of the technology

Superfast design and discovery of highly efficient drug candidates


Life Sciences and Biotechnology, Medicine

Laboratory of Molecular Modeling and Drug Design, School of Pharmacy, Faculty of Medicine

Research Capabilities

  • Developing and applying novel optimization algorithms for the design and discovery of novel therapeutics, from small molecules and peptidomimetics to peptides and proteins.
  • Ability to produce focused libraries of potentially highly active ligands for specific targets in a matter of days
  • Collaborating with researchers on treating diseases such as cancer, Alzheimer's and others
  • Solving complex problems in structural biology: protein-ligand interactions and docking, protein-protein recognition, predicting unstructured proteins


The lab's proprietary core technology, called Iterative Stochastic Elimination (ISE), is used to find optimal solutions to diverse issues such as sets of best ligands for a target, molecular conformational ensembles and properties, multiple loops in proteins, protein-ligand docking, protein design, focused libraries, chemoinformatics and others. ISE finds global and local minima and produces very large sets of optimal solutions from which to choose based on needs and requirements.

Research Background

The laboratory has expertise in a broad field of life sciences ranging from physics and chemistry to biology and structural biology, and includes computer science experts.

Researcher and Research Interests

Professor Amiram Goldblum, Institute for Drug Research, School of Pharmacy. Professor Goldblum's optimization algorithm received the first prize of the American Chemical Society's Computational Chemistry Division in 2000. Since then, it has raised interest for use in many other fields including electronic circuits and investment portfolios. Professor Goldblum's main interests lie in the properties of molecules, intermolecular interactions and catalysis. For many years he used a quantum mechanical approach to his studies whereas recently his focus has been on molecular mechanics solutions.

Available Resources

The laboratory has a large computer cluster for its algorithm developments and applications.

Laboratory Contact

Professor Amiram Goldblum, amiram.goldblum@ekmd.huji.ac.il, +972-2-675-8701

Project manager

Itzik Goldwaser
VP, Head of Research Collaborations

Project researchers

Amiram Goldblum
HUJI, School of Medicine - IMRIC
School of Pharmacy- Institute for Drug Research

Related keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Clean Industrial Technologies
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Clinical Medicine
  • Anatomy, Pathology, Immunology, Physiology
  • Agro and Marine biotech
  • Other Medical/Health Related
  • Therapeutic
  • Diagnostic
  • Other (uncategorised)
  • Research Collaboration
  • Life Science & Biotechnology

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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