Yissum - Research Development Company of the Hebrew University

Controlled Release Technology for Oral Applications

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Liquid precursor composition that upon solidification forms a sustained release varnish


Project ID : 6-2009-2241

Description of the technology

Delivers treatment in response to pH conditions in mouth


Coatings, Biomaterials, Polymers, Composites, Dental Care

Development Stage

Successful clinical trials – ready for commercialization

Patent Status

Patent pending


  • Novel dental coating that delivers therapeutics over time, as required, in response to sensed changes in acidic/basic conditions in the oral cavity
  • Dental disorders occur when there are changes in oral hygiene, diet, medicaments or age
  • The main advantage of current therapeutic agents and drug delivery systems is their high substantivity in the target organ, in contrast to the applications currently used.
  • Application-targeted reagent is suitable for oral disorders as: tooth decay, periodontal diseases, implantitis, halitosis, tooth whitening, hypersensitivity, cancer, fungal infection, repair and regeneration of bone, cartilage, tendon and ligament defects.

Our Innovation

The application is a pharmaceutical platform that various types of drugs can be incorporated into.

Key Features

  • Increases exposure time to medication, preventing infections even in procedures in the root canal
  • Enables sustained release treatment effective against bacteria, yeasts, viruses and fungi
  • Reduces amount of drugs required, minimizing side effects. These advantages result in better clinical improvement and better patient compliance.
  • Built-in pH sensor increases the rate of release of medication in response to changes in pH that occur in many pathological oral disorders such as infections, caries, inflammations, dry mouth, halitosis, candidiasis, delivering medication as required
  • Simple production process; straightforward scale-up

Development Milestones

Seeking industry cooperation for commercialization

The Opportunity

Additional applications in medicine in human or in animals

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Doron Steinberg
HUJI, Faculty of Dental Medicine
Institute of Dental Sciences

Michael Friedman
HUJI, School of Medicine - IMRIC
School of Pharmacy- Institute for Drug Research

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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