Yissum - Research Development Company of the Hebrew University

Small novel molecules (Thiazolidinediones) for Prevention and Destruction of Bacterial Biofilms (in all modes of administration)

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Small compounds that interfere with QS, therefore, offer a new approach to the development of novel antimicrobial and anti-biofilm agents

TZD10 was found to be highly active
Project ID : 12-2007-1866

Description of the technology


  • Quorum sensing takes place in biofilms where microbes such as bacteria and fungi are at close proximity to one another
  • Inter species quorum sensing may affect microbes’ physiology and virulence properties, resulting in the enhanced virulent properties of biofilms
  • Prevents formation of biofilms as well as disruption of existing biofilms
  • Many applications in health, water systems, for sterilization of large surfaces, such as walls and floors, in prevention of biofouling and bioerosion

Our Innovation

Synthesis of novel thiazolidinediones that present a new anti-microbial approach by interfering with the quorum sensing of bacteria and fungi in biofilms.

Application for use:

  • Development for use as a non-antibiotic approach to infection therapy.
  • Medical applications to prevent biofilms in catheters and tubing; large surface sterilization.
  • Useful in any water system to counteract biofouling – filtration membranes, air conditioning, desalination and more...
  • Prevention of biofouling of irrigation systems using recycled water.

Key Features

  • Compounds used are not lethal to bacteria – they are used at concentrations lower than the MIC (minimal inhibitory concentration) - greatly reduces the development of resistance.
  • Can be used together with known antibiotics and biocides at much lower concentrations.
  • May be used to prevent formation of biofilms as well as disruption of existing biofilms.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Doron Steinberg
HUJI, Faculty of Dental Medicine
Institute of Dental Sciences

Morris (Late) Srebnik
HUJI, School of Medicine - IMRIC

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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