New vanadium complexes in the treatment and prevention of diabetes
Civilization diseases are defined as occurring globally, widespread diseases, and affects not only older people or adults, but also teenagers and even children. Treatment of most of them is difficult, slow and also very costly. The civilization diseases are: cardiovascular, respiratory, gastrointestinal, allergic and infectious diseases, diabetes, obesity, cancers and mental health problems. It is estimated that these diseases are the cause of more than 80% of all deaths (according to the World Health Organization). Each risk of developing one of the civilization diseases significantly increases the risk of developing another. Therefore it is so important to implement the pro-health politics, promotion of healthy lifestyle and an appropriate pharmacotherapy. Unfortunately, the currently used pharmacological agents are affected by many disadvantages, which show the need for continuous search for drugs with greater efficacy and favorable safety profile. One of the possible strategies for development of innovative therapies is the identification of drug candidates that inhibit the activity of phosphatases, the enzymes responsible for the course of many reactions in the body. The phosphatases inhibit the activity of many cellular proteins, which is one of the basic regulatory mechanisms of the cells. They influence the regulation of numerous signal transduction pathways that determine basic functions of cells, including metabolism, cells division and their death by apoptosis. These mechanisms are also responsible for the formation, development and the course of many disorders and diseases. Thus, modulation of them may be an effective preventive and therapeutic strategy.