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 | Seeking bio-based/biodegradable coating and adhesive solutions for flexible PHA films used in food packaging |
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We are seeking bio-based/biodegradable coating and adhesive solutions for flexible PHA films used in food packaging to achieve our sustainability goals of 100% recyclable, compostable, biodegradable, or reusable (RCBR compliant) materials and 20% greenhouse gas emission (GHG) reduction by 2030. |
| | Seeking novel bottle and/or bottle closure sanitation methods that reduce or eliminate the use of chemicals and/or water in the sanitation process |
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PepsiCo is seeking novel bottle and/or bottle closure sanitation methods that reduce or eliminate the use of chemicals and/or water in the sanitation process. It is very important to sanitize packaging containing beverages intended for human consumption. Failure to adequately sanitize bottles and bottle closures to remove bacteria, viruses, molds, yeasts, and spores may have serious consequences with respect to product quality and safety, potentially leading to negative customer reactions or even product recall. Peracetic acid (PAA) is a commonly employed and highly effective sanitizer, particularly when used in conjunction with hydrogen peroxide. However, PAA sanitation processes involve a significant amount of water throughout the process including dilution, water rinsing of packaging post-treatment and chemical disposal. Globally, trillions of gallons of beverages are bottled each year. While preserved carbonated soft drinks (CSDs) are the traditional leader in market share, other drinks such as bottled water, juices, non-preserved CSDs, and ready-to-drink teas and coffees are gaining in share. New inventions are needed to ensure that these drinks remain safe, while reducing unnecessary chemical and/or water consumption during production. Proposed solutions should achieve the following objectives: •Reduce or eliminate the amount of water used in bottle and/or bottle closure sanitation processes; and/or •Reduce or eliminate the use of chemicals in bottle and/or bottle closure sanitation processes. Solutions that may be in scope include wet chemical, dry chemical, plasma, UV, ebeam etc. PepsiCo is open to solutions from adjacent industries that may include long lasting hygiene solutions, surface hygiene solutions, coatings or packaging sanitation solutions. |
| | Seeking in-field tools to accurately measure citrus raw juice quality |
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Citrus fruit must be harvested when they are mature (ripe) and quickly processed so as not to compromise quality or incur yield losses due to fruit drop, pests, and diseases. Citrus fruit is non-climacteric and cannot be matured after it has been detached from the tree. Maturity is rated directly by measuring accumulated brix and titratable acidity both of which are important juice quality characteristics. The State of Florida defines maturity for oranges at a minimum brix of 9%. There are further definitions of processed orange juice by the FDA which define grades and products specifications. The brix and titratable acidity (TA) measurements in the field must be accurate to inform timely harvesting decisions. While there are available tools in the market to measure TA , brix or both parameters, they provide approximate values that are difficult to ascertain or may require complex machines, reagents and skilled end-users. Our goal is to identify or develop tools which can accurately measure TA and brix in the field expediently without requiring expert training. |
 | FOLDABLE PAPER-BASED DEVICE FOR DETECTION OF INFECTION IN BODY FLUIDS |
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A new and simple foldable paper-based fluidic device (InfectCheck), designed with only two foldable sections for an efficient separation and detection of the desired biomarker. |
 | Electrochemical biosensor for detection and quantification of alkylphenols |
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Fast, efficient and accurate method for the quantification of alkylphenols (APs). These sensors are based on a network of single-walled carbon nanotubes functionalized with a highly specific anti-AP antibody, which is at the core of the AP quantification reaction. This quantification is determined as a function of the changes in the electrical current, which varied according not only to the presence of absence of these com-pounds, but also in proportion to their concentration. |
 | LIH383: novel positive regulator of the opioid system modulator |
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LIH383 is a novel highly potent and specific negative modulator of ACKR3, developed by Dr Andy Chevigné, Head of Immunopharmacology and Interactomics, and Dr Martyna Szpakowska. It is an octapeptide (short chain of eight amino acids) with high selectivity and subnanomolar affinity for ACKR3. It was engineered by introducing a series of mutations to adrenorphin. Compared with other natural opioid ligands, its sequence (FGGFMRRK) confers it maximum specificity and affinity for ACKR3 and minimum selectivity and affinity for other opioid receptors. LIH383 therefore binds to and blocks ACKR3, thereby modulating the availability of opioid peptides that can bind to classical opioid receptors in the brain and potentiating their natural painkilling and antidepressant properties. LIH383 is therefore a positive regulator of the opioid system. In a nutshell, LIH383 presents the following advantages: > Subnanomolar potency > High selectivity for ACKR3 > Short chain (8 amino acids) > Easy to synthesise/customise |
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