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O-1104IK4 - IKERLAN / Spain 948

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Precision Molds for Soft-Lithography and Hot Embossing of Microstructures

microfabrication, Cell, Cell culturing, lab on a chip, micropatterning, soft-lithography, microstructures, microfluidic, microfluidic devices, polymer molds, Microbiology, molecular biology
- Description of the technology offer :
  
  Custom-made rigid polymer molds with micrometer resolution for low-volume fabrication of microfluidic devices and microstructures. Techniques comprise soft-lithography (casting of elastic polymers) or hot embossing. Proprietary technology for highly complex micropatterning, with various levels of features.
  
  Molds are highly resistant and thermally stable for excellent replication quality. Durability depends on application, please consult. Proven technology in various research and industrial projects.
  
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  Affordable and convenient solution for the development of high resolution molds for low volume fabrication of microstructures. The mold fabrication method is optimized to ensure dimensional stability under moderate temperatures (<160ºC). The mold material has good optical transparency and resistance to common organic solvents (acetone, methanol, isopropanol). Read more
O-1105Knowledge Innovation Market / Spain 1042

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Customized Automotive Lighting: New Marketing Tool

car brand, car lighting, automobile, LED, LEDs, automotive marketing, lighting, automotive lighting
- Description of the technology offer :
  
  The invention consists in a new configuration of LEDs included in the automotive lighting system that allows conforming capricious shapes such car brands or other designs. The customization of the lighting system, including the car brand for an instance, is a powerful and innovative marketing tool, free and with an effective dissemination, that may have an important impact on the global car´s market.
  
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  Currently there are different models of lighting brand logo in cars, but this technology is the only one designed to create the brand logo directly thought a LEDs configuration.
  
  Referring to the Commission Directive 2008/89/EC of 24 September 2008, vehicles manufactured from February 2011 have to incorporate a lighting system for being driven during the day that will automatically switch on the lights at starting the car in order to improve visibility and increase safety on the road. This invention takes full advantage of the new regulation. Read more
O-1102University of Alicante / Spain 962

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New process for the stereoselective synthesis of acetylenic compounds used as additives in galvanic baths

Organic compounds, electrolysis, electrochemical, electrochemical synthesis, electrocatalysis, electrochemistry, galvanic, galvanic baths, acetylenic compounds, organic chemistry, Oxidation, nickel, electroplating, metal industry, Automotive
- Description of the technology offer :
  
  The research group of Applied Electrochemistry and Electrocatalysis of the University of Alicante has developed a stereoselective process for the electrochemical synthesis of 3-(2-propynoxy)-2-propenoic acid and/or mixtures of acetylenic compounds (the same acid and propargyl alcohol) through one step. This synthesis does not use permanganate as oxidising agent, avoids extreme conditions of reaction and minimises the residues management. The electrochemist group is looking for companies interested in acquiring this technology for commercial purposes or for establishing projects to adopt this technology to their needs.
  
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  Regarding the existing state of the technique, the electrochemical processes have characteristics which make them very adequate to be applied for the synthesis of organic compounds with industrial application. Here, oxidation processes occurs upon electrodes named anodes where the substance which must be oxidized loses its electrons on the anode without needing conventional oxidising agents. Therefore, contaminants derived from the use of conventional oxidising agents are not generated and hence, no need for the management of hazardous residues is applicable.
  
  On the other hand, the electrochemical processes are developed under soft conditions (atmospheric pressure and room temperature) and clearly facilitate further processes of separation of one of the compounds of the reaction mixture.
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O-1114Fundació UdG Medicina / Spain 499

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PSICODEM allows you to choose the most appropriate psychosocial intervention for people suffering from dementia

Software, Psychosocial Interventions, Dementia, Alzheimer
- Description of the technology offer :
  
  PSICODEM is a very simple software. It allows you to choose the most appropriate psychosocial intervention for people suffering from dementia, depending on their level of cognitive impairment and other signs and symptoms such as aphasia, anxiety or depression. Potential users are decision-making professional who manage dementia. Evidence-based interventions have been reviewed and most efficient ones are tailored recommended for each patient specific charactaristics.
  
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  It is a very simple software. It does not needt to be installed, just needs internet access, together with a user name and password. It is very easy to use and very useful when professionals need to take quick decisions based on best existing evidence. They have to consider level of patient's dementia according to MMSE test and study their signs and symptoms in order to obtain the best psychosocial intervention that is recommended. Read more

Featured innovation provider University of Alcala

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O-1110University of Seville / Spain 1086

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New method of diagnosis of neuromuscular diseases

neuromuscular, neuromuscular diseases, diagnostics, Diagnosis, histological, tissues, biopsy
- Description of the technology offer :
  
  CSIC, in collaboration with the Andalusian Public Health System and the Universities of Seville, have developed a procedure to diagnose, in an automatic way, different neuromuscular diseases and their degree of involvement. The method is based on the application of the network theory to characterize the organization of tissues and enables to perform comparative histological studies from biopsy of skeletal muscle tissue of a patient. The method presented eliminates the subjectivity with which these diseases are currently diagnosed.
  
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  At present, the diagnosis of neuromuscular diseases is based on visual interpretation, by the pathologist specialist, of the morphological evaluation of biopsies from patients. It incorporates a certain level of subjectivity in the diagnosis of the involvement degree of the disease. Ultimately the diagnosis can not be quantified in an objective manner.
  The invention presents a method of analysis for diagnosing neuromuscular diseases. The method is based on recent findings that demonstrate the applicability of the network theory to the characterization of tissues. In this way, it is possible to obtain new specific parameters able to characterize a biopsy of skeletal muscle tissue from a patient and compare it to a healthy one. From this comparison it is possible to determine objectively possible muscle diseases and their degree of involvement.
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O-452CIBER-BBN / Spain 1825

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New compound material by polymer and metallica particles for biomedical applications

implants, biomedical devices, polymeric matrix, biomaterial.
- Description of the technology offer :
  
  The present invention refers to a material with a polymeric matrix and metallic particles. It provides a biocompatible and bio-degradable material for the manufacturing of useful devices for medical applications such as material for bone-synthesis and tissue engineering for the regeneration of bone tissue.
  
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  - Mechanical properties and degradation speed can be modulated by the composition.
  - Bone conductive properties.
  - Play, as well, a role of scaffold during the regeneration process (present when using conventional metallic alloys)
  - No stress shielding.
  - Electromagnetic fields can be used in post surgery diagnosis.
  - Biocompatible and biodegradable. Read more
O-1174University of Alicante / Spain 51

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Innovative thermal conditioning panel in ceramic material able to cool or heat any environment in a simple, sustainable and energy-efficient way

ceramic, panel, heating, Ventilation, insulation, thermal energy, building
- Description of the technology offer :
  
  Several Spanish institutions have developed an innovative thermal conditioning panel in ceramic material able to cool or heat any environment in a simple, sustainable and energy-efficient way. It requires minimal maintenance and can be deployed using a wide range of designs and configurations. Important advantages are achieved in terms of lightness, aesthetics and cleanliness. They are mainly looking for companies licensing the technology, although, they are also open to technical collaboration.
  
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  The main advantages of this technology are:
  
  - The technology consists of a cooling and heating system more sustainable and efficient. This system allows the usual air conditioners, forced air convective or hot water radiators to be replaced.
  - The installation and fastening system is very simple, so the panels could be easily mounted and dismounted.
  - Panels can be arranged horizontally, vertically or any other inclination, applied on walls and ceilings.
  - The use of ceramic materials enables greater lightness, so it can take larger formats (up to 300 x 100 mm; thickness 3 to 5 mm)
  - Ceramic material panels are more resistant to the effects of humidity, condensation, adsorption of dirt and moisture, as well as a higher mechanical strength.
  - Ceramic materials provide greater flexibility in terms of aesthetics and design, so different colour, texture or image could be applied to the walls and ceilings of a room. Read more
O-1183Advanced Marker Discovery, S.L. / Spain 46

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Prognostic test for identifying early stage II colorectal patients in high risk of recurrence.

biomarker, Diagnosis, prognosis, oncology, cancer, colorectal
- Description of the technology offer :
  
  The recommended treatment for stage I and II colon cancer patients is surgical intervention and the routine use of adjuvant chemotherapy for stage II is not recommended by clinical guidelines. However, a proportion of 25% of stage II patients experiences recurrence and dies due to this disease. Even in patients with similar clinical and pathological features outcome is radically different, implying that new molecular methods are necessary to select stage II patients at high risk who could benefit from adjuvant chemotherapy (ACT). Moreover, selection of patients to be treated avoids the additional costs and patient suffering associated with under-treating them.
  
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  Biomarker over-expression plays a relevant role in early-stage CRC demonstrating a clear and significant association between over-expression of the enzyme, and recurrence and worst death rate ratio.
  
  Amadix is now evaluating the value of KIAA 1456 as a marker for predictive response of chemotherapy indication and for indication in stage III as prognostic and predictive of clinical outcome marker . Interim results shows clear promise and may offer partners additional untapped potential.
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Featured innovation provider University of Salamanca

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O-1182Advanced Marker Discovery, S.L. / Spain 44

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Prognostic test for identifying early stage Non-Small Cell Lung Cancer (NSCLC) patients in high risk of recurrence

biomarker, Diagnosis, prognosis, oncology, cancer, lung
- Description of the technology offer :
  
  Early-stage NSCLC patients are treated primarily by surgical removal of their tumors, but nearly half of all these patients will develop recurrent disease (30% to 40% of stage I patients). These recurrence rates imply that patients diagnosed with the same stage of disease have markedly different treatment responses and overall outcomes.
  There is a real need for a prognostic tool that will enable physicians, using this marker, to identify stage I NSCLC patients (previously treated only with surgery) with a risk of recurrence that may benefit from adjuvant chemotherapy (ACT).
  Moreover, selection of patients to be treated avoids the additional costs and patient suffering associated with under-treating them.
  
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  The overexpression of this new biomarker is a new independent prognostic factor for identifying early stage NSCLC patients in risk of recurrence.
  There is a significant correlation of biomarker expression in patients suffering from stage I NSCLC and worse clinical outcome.
  The patient stratification would allow the physician to give a more aggresive treatment to those patients with a high risk of recurrence and to avoid the unnecesary toxicity associated with antitumoral treatment for those patients with good prognosis. Read more
O-1184University of Burgos / Spain 65

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Microencapsulation of enzymes to accelerate cheese maturation process

cheese, maturation process, Microencapsulation, Enzymes
- Description of the technology offer :
  
  Researchers at the University of Burgos are developing a technology of microencapsulation of proteolitic enzymes that reduces time cheese maturation process, maintaining their organoleptic characteristics.
  
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  Application of microencapsulation to control the function and action of the enzymes involved in cheese ripening and shorten processing times. The addition of encapsulated enzymes eliminates the problems associated with the direct addition (loss of enzyme in serum, bad distribution, reduced performance and quality alteration cheese) allowing a gradual and control action, reducing time maturation and therefore giving a quicker exit of the product to market.... Read more
O-1153University of Louisiana at Lafayette / United States 477

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Asymmetric Synthesis of N-substituted Allylic Amine Compounds

amination, amine, Chiral, chiral amine, petrochemical, fine chemical, agrochemicals, pharmaceutical compounds, olefins, aryl, alkene, esters, asymmetric allylic
- Description of the technology offer :
  
  Many natural products, including pharmaceutical compounds and agrochemicals contain chiral amine functionality. Thus, the asymmetric (chiral selective) amination of olefins has received significant attention from diverse industries. Recently, researchers at the University of Louisiana at Lafayette have developed a novel method of asymmetric synthesis of N-substituted allylic amine compounds. And, this method offers numerous technical advantages over current asymmetric methods, including asymmetrical synthesis of N-aryl-substituted allyl amines and non-natural Beta-aminoacid esters.
  
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  Technical Advantages include:
  ***Reduced number of synthesis steps; utilization of inexpensive compound rather than expensive transition metal complexes as chiral catalysts;
  ***Reduces wasteful synthesis of distomer enantiomer; ideal for syntheses utilizing expensive and/or precious starting material;
  ***Advantageous for synthesis of allylic amine compounds with multiple chiral centers where chiral HPLC separation is problematic
  ***Uniquely effective for synthesis of asymmetrical N-aryl-substituted allyl amines;
  ***May also be used in the production of non-natural chiral Beta-amino acid esters, chiral heterocycles, bioactive molecules or materials. Read more
O-1154University of Louisiana at Lafayette / United States 609

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Dendritic Magnetic Nanostructures and Method for Making Same

Nanorods, dendritic, magnetic nanostructures, nanoparticle, Nanostructures, Nanowires, nanotubes, nanomanufacturing, electrochemistry, chemical vapor deposition, supercapacitors, chemical, Chemistry
- Description of the technology offer :
  
  Magnetic nanostructures comprised of an assembly of magnetic nanorods held together by dipole forces in a dendritic pattern and their method of manufacture is described. The dendritic magnetic nanostructures are prepared at room temperature by applying a magnetic field to a reverse micelle system wherein at least one salt of a magnetic metal is being precipitated within the core of the reverse micelle. This manufacture method offers signfifcant technical advantages over existing systems.
  
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  Quasi one-dimentional magnetic nanostructures, such as nanorods, nanowires, and nanotubes have attracted significant scientific and technological interest because they exhibit unique magnetic properties not displayed by their bulk or nanoparticle counterparts. A variety of methods have been proposed for synthesizing various types of nanorods. And, while these methods have yielded varying degrees of success, they all are faced with the same common problems associated with chemical and physical processes, such as high cost, aggregation and coarsening of particles at elevated temperatures, and shape control, all of which limits their applications. We present here a novel fabrication method based on the reverse micelle method to produce magnetic nanorods of a dendritic fashion in repose to an applied magnetic field at room temperature. This technology offers an efficient, cost-effective method of nanostructure fabrication, and also for magnetic nanostructres having unique morphologies, that hold great potential for reducing costs of nanostructure manufacturers. Read more

Featured innovation provider University of Dundee

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O-1155University of Louisiana at Lafayette / United States 796

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Nanostructure for Ultra-High Density Storage Media

FeRh, FePt, recording, recording media, magnetic recordings, Storage, storage media, magnetic storage, Nanostructure, hardware, Electronics, computer science, nanoparticles
- Description of the technology offer :
  
  In heat assisted magnetic recording (HAMR), FeRh-FePt composite particles are extensively used to increase thermal stability and overcome the write field limitations in both longitudinal and perpendicular magnetic recordings. Spherical nanoparticles offer magnetically isotropic media with functional advantages over conventional particles. Thus, the synthesis of spherical FeRh-FePt composite nanoparticles offers significant potential for increased magnetic storage media stability and function. This current technology offering includes methods and processes for making FeRh/FePt core shell nanostructures and their use as an ulta-high density storage media.
  
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  In HAMR, both the coercivity and saturation magnetization of FePt are lowered during the heating process.However, the lowering of saturation magnetization of FePt reduces the thermal stability of the FePt media and therefore the ability of the FePt media to maintain written data over time. By magnetically coupling FePt with FeRh, the saturation magnetization of the FeRh--FePt system is increased over that of FePt alone, resulting in an increase in the thermal stability of the magnetic recording media and solving the write-ability problem.Therefore the synthesis of FeRh and the magnetic coupling of with FePt overcomes the write field limitations in both longitudinal and perpendicular magnetic recordings. This current technology offering includes methods and processes for making uniformly spherical FeRh/FePt core shell nanostructures and their demonstrated use as an ultra-high density storage media. This technology has significant potential as a ultra-high density storage media. Read more
O-1156University of Louisiana at Lafayette / United States 674

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Low-power, high-performance flip-flop using only a single clocked transistor

transistor, flip, flop circuit, clocked
- Description of the technology offer :
  
  The clocked transistors within a flip-flop have 100% switch activity and present a huge load on the clock distribution network. If one can reduce the number of clocked transistors in a flip-flop, the clock tree will have less capacity load and hence reduce the power consumed in the clock network.. This invention provides a low power, high performance flip-flop circuit using only one clocked transistor.
  
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  Power consumption is a major concern in modern processors. Processor clock systems, consisting of flip-flops and latches, consume a large amount of power in modern processors. If one can reduce the number of clocked transistors in a flip-flop, the clock tree will have less capacity load and hence reduce the power consumed in the clock network. This will further result in reducing the number and size of the clock driving buffers, which will in turn cause a significant reduction in the power consumption of the overall system. We have invented a single-transistor-clocked flip-flop that enables minimizing of redundant switching activity, reduction of glitches at the output node, and less power consumption than current flip-flop devices. Collectively, this technology provides a low power, high performance flip-flop circuit with significant potential to increase circuit and overall system reliability, efficiency and speed. Read more
O-1188University of Seville / Spain 252

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Method for diagnosis of early Parkinson’s disease

Parkinson, Diagnosis, pharma,
- Description of the technology offer :
  
  A research group of the Andalusian Public Health System, in collaboration with the University of Seville, has developed a method for the diagnosis of Parkinson’s disease (PD) which comprises the quantification in blood, serum or plasma levels of nitro-α-synuclein nitrosylated at Tyr125 and/ or Tyr136.
  
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  There is an unmet medical need of developing new alternative biomarkers useful for the reliable diagnosis of Parkinson’s disease at early stages of the disease. The present technology relates to the use of specific antibodies against the nitronitrosylated α-synuclein residues Tyr125, Tyr136, and/ or Tyr39 in the preparation of a pharmaceutical composition for the treatment of PD. Read more
O-887UATEC - Technology Transfer Office of University of Aveiro / Portugal 1019

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Innovative method for extraction of triterpenic acids

Eucalyptus, bark, triterpenic acids, ursolic/oleanolic acid, chemical extraction, fitopharmaceutics, Phyto-pharmaceutical and cosmetic industry, Pulp industry
- Description of the technology offer :
  
  The present method makes use of a simple set of unitary operations that allow an efficient, selective and economic extraction of triterpenic acids from eucalyptus bark. In addition, it makes usage of agro-industrial residues which are normally under exploited. The process can be easily integrated in the industries where the residues are abundant.
  
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  It is a process that, with a simple set of unitary operations, allows to get extracts with high triterpenic acids contents , from crude extracts of eucalyptus bark. This process can be easily integrated with existing pulp production, allowing even the subsequent exploitation of bark for energy production. Read more

Featured innovation provider IK4-IKERLAN

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O-971University of Dundee, Research and Innovation Services / United Kingdom 1423

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FMN-2: Novel Platform for the Development of Cancer Diagnostics/Therapeutics

cancer diagnostics, cancer therapeutics, tumor suppressor, cancers, ARF tumour, cell proliferation disorders, tumour supressor, tumour
- Description of the technology offer :
  
  Researchers at the University of Dundee have identified a novel and important component of a central tumor suppressor pathway. This discovery has the potential to impact upon the detection and development of novel treatments for a wide range of cancers and other disorders.
  
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  Researchers at the University of Dundee have identified a novel and important component of the ARF tumour suppressor pathway – the ARF-induced Formin-2 (FMN2) protein. Expression of the FMN-2 gene has been found to be upregulated upon induction of the ARF tumour suppressor via a mechanism that is independent of p53.
  
  Investigation has shown that elevated FMN2 expression can occur in multiple forms of cancer as well as in model tissue culture systems. Detection of elevated FMN2 levels may be useful as a cancer diagnostic and FMN2-based therapeutics may have the potential to benefit a wide range of cell proliferation disorders. Read more
O-738University of Girona / Spain 1373

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Recombinant non-genotoxic antitumor agents based on human pancreatic ribonuclease

Anticancer drug, recombinant protein, different types of cancer, multidrug resistance phenotype
- Description of the technology offer :
  
  We have engineered and developed variants of human pancreatic ribonuclease with antitumor activity. These ribonuclease variants are endowed with an NLS that directs the protein to the nucleus of the cells where they induce cell apoptosis. These novel anticancer produce pleiotropic effects on cancer cells and are appropriate to treat the multifactorial cancer disease. We are interested in licensing the products.
  
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  The ability of the human ribonuclease variants to degrade nuclear RNA is the basis of a therapeutic approach for the treatment of cancer. Our ribonucleases are non-genotoxic drugs and it is though very difficult that they may generate drug resistance phenotype onto the treated cells. In addition, its human origin warrants poor or null immunogenicity in clinical uses. Their mechanism of action is different to that of other ribonucleases that are currently being assayed in clinical trials as anticancer drugs, like onconase or other RI-evading ribonucleases. This is because our ribonucleases act by destroying nuclear RNA instead of cytoplasmatic RNA and therefore produce different effects on treated cells. Read more
O-898Altus Formulation Inc / Canada 2018

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Novel Tamper and Abuse Resistant Delivery Technologies for Improved Patient Safety

Drug delivery, drug formulation, Abuse resistant, tamper resistant, pharmaceutical, pain
- Description of the technology offer :
  
  Altus is a full service contract development company using our patented, commercially validated drug delivery technologies to develop new 'safer to use' formulations for our clients drugs. Altus’ Intellitab technology provides the benefits of 12-24hr controlled and immediate release tablets, the differentiation and dosing flexibility of scoring and the peace of mind that comes through robust tamper resistant and abuse resistant features
  
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  Intellitab(TM) - Scored Crush, Tamper and Abuse Resistant Formulations that Prevent Dose Dumping
  
  Intellitab technologies allow, for the first time, stable scored controlled release tablets which may be broken without a change in performance – tablet pieces remain bioequivalent to the intact tablet. The hard Intellitab tablet resists breakage through chewing but if crushed and swallowed maintains controlled release with no change in peak levels of drug in the body. Further Intellitab technology robustly resists drug extraction in a range of solvents and liquids ,whether hot or cold, and prevents injection and euphoria through inhalation or insufflation.Immediate release tablets that prevent injection and the aims of insufflation are also available.
  
  By mitagating medication error, deliberate or inadvertant, Intellitab makes medications safer to use for the legitimate patient and protects those attempting non-medical use.
  
  Products approved on the Intellitab platform have obtained new class labeling from FDA based on their PK performance post breaking. Manufacturing utilises conventional equipment and processes to minimize cost of goods allowing the most appropriate price point for your drug.
  
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O-1159University of Louisiana at Lafayette / United States 668

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Smart card read / write controller and process

Smart card, card, controller, read, write, magnetic strips
- Description of the technology offer :
  
  Microcontroller to read/write data from/to a plurality of tracks contained on magnetic strip value card. The microcontroller device includes an input capture port for storing data read from the card, and wherein the microcontroller device continually poles the input capture port for an event to occur. This invention integrates the entire read/write system - the controller design, the steps for processing the signal, and writing to the stripes - into one single chip that accounts for varying swipe-speed with time
  
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  This novel invention takes advantage of the development in integrated circuits microcontrollers, and the development in hard disk technology namely magnetoresistive read heads. A debit card read/write controller. The controller comprises a microcontroller device, a read only memory, a dynamically random access memory and a read/write head for reading and writing onto a magnetic card media contained on a magnetic striped card. The microcontroller device includes an input capture port for storing data read from the card, and wherein the microcontroller device continually poles the input capture port for an event to occur. This invention integrates the entire read/write system - the controller design, the steps for processing the signal, and writing to the stripes - into one single chip that accounts for varying swipe-speed with time Read more

Featured innovation provider University of Almeria

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O-380BIOPOLIS, S.L. / Spain 3153

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Probiotic Bifidobacterium bifidum against Helicobacter pylori

Biotechnology, microbial, Bifidobacterium bifidum, probiotics, Helicobacter pylori
- Description of the technology offer :
  
  Novel probiotic Bifidobacterium bifidum CECT7366, eradicating pathogenic bacterium Helicobacter pylori.The use of probiotic Bifidobacterium bifidum CECT7366 is a potentially promising tool to prevent H. pylori infections. The research has revealed that strain B. bifidum CECT7366 is a probiotic bacterium with functional activity against H. pylori in vitro and even in vivo in a murine infection model.
  
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  Currently, antibiotic-based treatment of H. pylori infection is neither sufficient nor satisfactory;
  the most successful treatments reaching 75 to 90% eradication rates. Alternative or complementary approaches to antibiotic therapy are being assessed. In this respect, the use of probiotics is a potentially promising tool to prevent H. pylori infections. BIOPOLIS selected a probiotic strain that hampers H. pylori growth in vitro and identified the nature of the metabolites responsible for this inhibitory activity. We also used a murine model to demonstrate its capacity as well as its toxicological innocuousness. Read more
O-448Ciber-BBN / Spain 1965

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New procedure for obtaining a biomaterial with metallic coating - aplicattions in Implants, orthopaedic devices and prosthesis

Biomaterials, metallic coatings, orthopaedic devices, implants,
- Description of the technology offer :
  
  The present invention refers to a procedure for obtaining a biomaterial with metallic coating, by means of a metallurgic method comprising the immersion of a metallic substrate, based on titanium, in a melted alloy of silicon and aluminium. Besides, the present invention refers to the use of this biomaterial for medical applications.
  
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  - Specificity and effectiveness to obtain a biomaterial based in a titanium substrate with a metallic coating.
  - Hardness and ductility for the biomaterial.
  - Coating is persisten to corrosion, and biocompatible.
  - Thermal treatments in the procedure allow relaxing the residual tensions and increases the thickness of the coating. What significantly affects the superficial properties and the biological response. Read more
O-1049University Pablo de Olavide / Spain 1099

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Novel multi-screen device for animal experiments in neuroscience research

neurophysiology, neurophysiological, neuropsychology, neuropsychological, Neuroscience, animal experiments, neuroscientific, laboratory animals, metacognition, animal learning
- Description of the technology offer :
  
  This invention refers to a novel multi-screen device for studying self-learning and the capacity for self-regulation of self-learning in mice, and even in humans, by means of classic and operating conditioning. The device comprises a virtual environment where the subject to be studied is immersed, making it possible to visualise elements in touchscreens, using a software and as a function of mental impulses, in a fast and flexible manner, without requiring mechanical handling.
  
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  • This invention makes it possible to explore the neuropsychological processes in the subject under study through the introduction of objects in touchscreens, as a function of its mental impulses. Thus, animals can, for the first time, interact conceptually with a virtual learning interface.
  • Using the device, the presentation of stimuli can be changed in a flexible manner, through the use of software, and experiments can be designed by means of animal interaction with the screens and the virtual environment.
  • In addition to exploring the behaviour of laboratory animals, this device can be used to explore that of human beings, by changing the scale, in an immersive environment of virtual reality. Thus, perception studies, therapies and ludic applications of virtual games can be performed.
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O-1187University of Seville / Spain 348

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Method for diagnosis of severity of Parkinson’s disease

Redox, Parkinson, halogenation, Diagnosis, Kit
- Description of the technology offer :
  
  A research group of University of Seville and medical Andalusian health service, have recently demonstrated that there is an altered Redox state in serum of patients with early Parkinson’s disease, characterized by halogenative and nitrosative stress, together with anomalous nitrosylation of serum alpha-synuclein.
  
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  Protein and amine halogenation is a type of oxidative stress induced by phagocytic over-stimulation,
  and its role in Parkinson’s disease has not been discerned. Researchers propose the need for a development of a easy kit for rapid measuring of AOPP in serum of patients, which would allow following-up each patient in order to discern severity of the disease. Read more

Featured innovation provider University of Lleida

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O-1175Syncoda Technologies / United States 345

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A portfolio of 200+ worldwide patents/applications covering SIM-card-based 2.4 GHz wireless mobile payment technologies allowing E-wallet capability addon to conventional cell phones

wireless, mobile payment, payment technologies, online payment, payment, smart phones, cell phones, SIM card, mobile credit cards, Mobile banking, mobile ticketing
- Description of the technology offer :
  
  Pioneer High-Frequency (e.g., 2.4 GHz) Mobile Payment Technology. Faster, More Secure Than Other Technologies (e.g., NFC). SIM-Card Based. Complete patent portfolio for licensing/sale. Complete technology transfer. Joint ventures/productions possible. Low cost: a few dollars to replace the SIM card. Complete package including 200+ Worldwide Patents/Applications directed to this technology
  
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  -Plug-and-play technologies (e.g., SIM-Card-Based Mobile Payment Add-On Capabilities)
  -Instead of getting a new phone with mobile payment capability, users can simply replace a SIM card, or plug in an add-on card, to add such capability to existing mobile phones
  -Fast Deployment on the user side: only need to replace the SIM card or add a sticker to the SIM card;
  -Fast Deployment on the POS side: no need to change the billing system; does not affect other applications
  -Achieving Range Control with Magnetic Field
  -Fast Data Flow with RF (e.g., 2.4 GHz)
  -Extra Layer of Security
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O-444CIBER-BBN / Spain 1613

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New micro-chamber device for cellular culture monitoring by nuclear magnetic resonance

NMR, cell culture, diagnostics, imaging, cellular culture, magnetic resonance, NMR, image techniques, drugs, nanoparticles, biological factors
- Description of the technology offer :
  
  The present invention comprises a micro-chamber device for cell culture allowing longitudinal long-term monitoring of the cellular system by NMR and other image techniques. Image analysis and metabolic studies can be performed. Effect of active agents, such as drugs, nanoparticles or biological factors, can be assessed. By using it, a better knowledge of physiological and pathological conditions will be acquired, helping for diagnosis and therapy.
  
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  Its made of biocompatible materials in which longitudinal long-term studies of cell cultures can be performed. It's of appropiate design and size for NMR equipment commercially available. It's a transparent material, therefore also useful for other microscopic technique. It has a diffusion system for the uniform distribution of cells. You can control physico-chemical properties of the culture by optic fibre sensors for pH, pO2, pCO2,pNO, or pSH2. High resolution and easily handle by users. Read more
O-1100Biomedical Engineering Research Centre / Spain 705

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Biofeedback systems for urinary incontinence treatment

Bioengineering, hospital, medical devices, clinicians, urologist, urology, urinary incontinence, urinary
- Description of the technology offer :
  
  A "Biofeedback for pelvic floor training" fully functional and competitive has been validated by clinical staff specialized in urology and tested on voluntary giving excellent results. The developed system has an added value in relation to other tele commercial solutions from a usability standpoint and also provides more versatile services personalized to the patient treatment. The system software has a simple user interface, with a friendly communication with the other stages transparent to the user. Also, the application includes numerous options that allow clinicians to make your task easier and faster.
  
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  The advantage of this new system compared to others, is the study of the signal from the abdomen to monitor whether the exercise is being performed properly. In addition to the signal displayed, it is used as a criterion for evaluating the quality of the exercises per-formed, thus fulfilling another requirement. Read more
O-1185CELEROMICS TECHNOLOGIES, SRL / Spain 508

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Automated Cell Counter for microscopes. Our system plugs to any laboratory microscope and is able to measure cell density or confluence in counting chambers, petri dishes, well plates, etc.

Microbiology, biology, laboratory, microscopy, microscope, microscopes, cell counter, molecular biology, genetics, counting chambers, petri dishes, well plates, Cell, Biotechnology
- Description of the technology offer :
  
  Automated Cell Counter for microscopes. Our system plugs to any laboratory microscope and is able to measure cell density or confluence in counting chambers, petri dishes, well plates, etc. No disposable or maintenance is required, no need to sacrifize cells to perform cell count, minimizing cell handling and eliminating cell contamination.
  
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  Our systems plug to any laboratory microscope.
  
  It is able to count from 1 to 1000 microns in particles analyzed with a single device.
  No need for disposable material or reagents : savings 500-2000 EUR /year.
  It is able to count inside the bioreactor : no need to open the container / sacrifize the culture to perform the count. Read more

Featured innovation provider IRIS Research & Development

About IRIS Research & Development

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Open innovation policy

O-1181Innovation Department - Hospital Clinic Barcelona / Spain 583

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New Test for the Prognosis of Chronic Lymphocytic Leukemia (CLL)

Healthcare, prognosis, Diagnosis, diagnostic test, diagnostics, leukemia, clinical protocols, epigenetics, Biomarkers, PCR, qPCR, oncologists, oncology, hospitals, medical centres
- Description of the technology offer :
  
  The present invention aims at developing a new diagnostic test in CLL for a better patient stratification into prognostic groups
  • This new tool is able to classify CLLs into 3 new prognostic groups: MBC-like, intermediate, and NBC-like, using only 5 epigenetic biomarkers
  • After 10 years only 20% of the patients from the MBC-like group, 43% from the NBC-like group, and 100% from the NBC-like group will need treatment
  • This stratification will allow a better management of the patients improving their quality of life and to rationalise the health care expenditure
  
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  The current classification of M-CLL (mutated) and U-CLL (unmutated) is not used in clinical protocols to decide upon patient treatment and follow-up. The possibility of a better diagnosis and prognosis of CLL would be very useful for the proper management of the patients.
  Follow-up checks could be done less frequently improving the quality of life of those patients that have a better prognosis, such as the MBC-like group.
  This test will allow to:
  - Improve the quality of life of CLL patients
  - Improve management strategies that are more adjusted to the biology of this disease
  - Reduce the health care costs Read more
O-848UATEC - Technology Transfer Office of University of Aveiro / Portugal 1309

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Developed New Scintillating Optical Fiber Dosimeter

Dosimetry, radiotherapy, cancer, optical fiber, security, hospitals, clinics, medical equipment
- Description of the technology offer :
  
  A group of researchers at the University of Aveiro has developed a dosimeter for low energy and low dose rates. The invention aims to monitor the dose levels, applicable to the field of nuclear physics and medical physics, particularly in radiotherapy. This device has also application in the dose control and monitoring in imaging systems based on ionizing radiation and in industrial control and monitoring.
  
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  The invention aims to monitor the dose levels, applicable to the field of nuclear physics and medical physics, particularly in radiotherapy. This device has also application in the dose control and monitoring in imaging systems based on ionizing radiation and in industrial control and monitoring.The advantages of this technology in relation to existing technologies, include the fact that it allows the application in brachytherapy modalities for which other devices are not sensitive enough or do not meet the requirements for in-vivo and real time dosimetry. Read more

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5TH NEW PRODUCT DEVELOPMENT AND INNOVATION MANAGEMENT

3rd Annual Alliance Management for Open Innovation in Pharma

XXIV ISPIM Conference, 16-19 June 2013, Helsinki, Finland: Innovating in Global Markets:

The 6th ISPIM Innovation Symposium – Innovation in the Asian Century

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microfabrication, Cell, Cell culturing, lab on a chip, micropatterning, soft-lithography, microstructures, microfluidic, microfluidic devices, polymer molds, Microbiology, molecular biology

car brand, car lighting, automobile, LED, LEDs, automotive marketing, lighting, automotive lighting

Organic compounds, electrolysis, electrochemical, electrochemical synthesis, electrocatalysis, electrochemistry, galvanic, galvanic baths, acetylenic compounds, organic chemistry, Oxidation, nickel, electroplating, metal industry, Automotive

Software, Psychosocial Interventions, Dementia, Alzheimer

neuromuscular, neuromuscular diseases, diagnostics, Diagnosis, histological, tissues, biopsy

implants, biomedical devices, polymeric matrix, biomaterial.

ceramic, panel, heating, Ventilation, insulation, thermal energy, building

biomarker, Diagnosis, prognosis, oncology, cancer, colorectal

biomarker, Diagnosis, prognosis, oncology, cancer, lung

cheese, maturation process, Microencapsulation, Enzymes

Researchers at the University of Burgos are developing a technology of microencapsulation of proteolitic enzymes that reduces time cheese maturation process, maintaining their organoleptic characteristics.

amination, amine, Chiral, chiral amine, petrochemical, fine chemical, agrochemicals, pharmaceutical compounds, olefins, aryl, alkene, esters, asymmetric allylic

Nanorods, dendritic, magnetic nanostructures, nanoparticle, Nanostructures, Nanowires, nanotubes, nanomanufacturing, electrochemistry, chemical vapor deposition, supercapacitors, chemical, Chemistry

FeRh, FePt, recording, recording media, magnetic recordings, Storage, storage media, magnetic storage, Nanostructure, hardware, Electronics, computer science, nanoparticles

transistor, flip, flop circuit, clocked

Parkinson, Diagnosis, pharma,

Eucalyptus, bark, triterpenic acids, ursolic/oleanolic acid, chemical extraction, fitopharmaceutics, Phyto-pharmaceutical and cosmetic industry, Pulp industry

cancer diagnostics, cancer therapeutics, tumor suppressor, cancers, ARF tumour, cell proliferation disorders, tumour supressor, tumour

Researchers at the University of Dundee have identified a novel and important component of a central tumor suppressor pathway. This discovery has the potential to impact upon the detection and development of novel treatments for a wide range of cancers and other disorders.

Anticancer drug, recombinant protein, different types of cancer, multidrug resistance phenotype

Drug delivery, drug formulation, Abuse resistant, tamper resistant, pharmaceutical, pain

Smart card, card, controller, read, write, magnetic strips

Biotechnology, microbial, Bifidobacterium bifidum, probiotics, Helicobacter pylori

Biomaterials, metallic coatings, orthopaedic devices, implants,

neurophysiology, neurophysiological, neuropsychology, neuropsychological, Neuroscience, animal experiments, neuroscientific, laboratory animals, metacognition, animal learning

Redox, Parkinson, halogenation, Diagnosis, Kit

wireless, mobile payment, payment technologies, online payment, payment, smart phones, cell phones, SIM card, mobile credit cards, Mobile banking, mobile ticketing

NMR, cell culture, diagnostics, imaging, cellular culture, magnetic resonance, NMR, image techniques, drugs, nanoparticles, biological factors

Bioengineering, hospital, medical devices, clinicians, urologist, urology, urinary incontinence, urinary

Microbiology, biology, laboratory, microscopy, microscope, microscopes, cell counter, molecular biology, genetics, counting chambers, petri dishes, well plates, Cell, Biotechnology

Healthcare, prognosis, Diagnosis, diagnostic test, diagnostics, leukemia, clinical protocols, epigenetics, Biomarkers, PCR, qPCR, oncologists, oncology, hospitals, medical centres

Dosimetry, radiotherapy, cancer, optical fiber, security, hospitals, clinics, medical equipment

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