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O-1153University of Louisiana at Lafayette / United States 418

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Asymmetric Synthesis of N-substituted Allylic Amine Compounds

amination, amine, Chiral, chiral amine, petrochemical, fine chemical, agrochemicals, pharmaceutical compounds, olefins, aryl, alkene, esters, asymmetric allylic
- Description of the technology offer :
  
  Many natural products, including pharmaceutical compounds and agrochemicals contain chiral amine functionality. Thus, the asymmetric (chiral selective) amination of olefins has received significant attention from diverse industries. Recently, researchers at the University of Louisiana at Lafayette have developed a novel method of asymmetric synthesis of N-substituted allylic amine compounds. And, this method offers numerous technical advantages over current asymmetric methods, including asymmetrical synthesis of N-aryl-substituted allyl amines and non-natural Beta-aminoacid esters.
  
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  Technical Advantages include:
  ***Reduced number of synthesis steps; utilization of inexpensive compound rather than expensive transition metal complexes as chiral catalysts;
  ***Reduces wasteful synthesis of distomer enantiomer; ideal for syntheses utilizing expensive and/or precious starting material;
  ***Advantageous for synthesis of allylic amine compounds with multiple chiral centers where chiral HPLC separation is problematic
  ***Uniquely effective for synthesis of asymmetrical N-aryl-substituted allyl amines;
  ***May also be used in the production of non-natural chiral Beta-amino acid esters, chiral heterocycles, bioactive molecules or materials. Read more
O-1154University of Louisiana at Lafayette / United States 551

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Dendritic Magnetic Nanostructures and Method for Making Same

Nanorods, dendritic, magnetic nanostructures, nanoparticle, Nanostructures, Nanowires, nanotubes, nanomanufacturing, electrochemistry, chemical vapor deposition, supercapacitors, chemical, Chemistry
- Description of the technology offer :
  
  Magnetic nanostructures comprised of an assembly of magnetic nanorods held together by dipole forces in a dendritic pattern and their method of manufacture is described. The dendritic magnetic nanostructures are prepared at room temperature by applying a magnetic field to a reverse micelle system wherein at least one salt of a magnetic metal is being precipitated within the core of the reverse micelle. This manufacture method offers signfifcant technical advantages over existing systems.
  
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  Quasi one-dimentional magnetic nanostructures, such as nanorods, nanowires, and nanotubes have attracted significant scientific and technological interest because they exhibit unique magnetic properties not displayed by their bulk or nanoparticle counterparts. A variety of methods have been proposed for synthesizing various types of nanorods. And, while these methods have yielded varying degrees of success, they all are faced with the same common problems associated with chemical and physical processes, such as high cost, aggregation and coarsening of particles at elevated temperatures, and shape control, all of which limits their applications. We present here a novel fabrication method based on the reverse micelle method to produce magnetic nanorods of a dendritic fashion in repose to an applied magnetic field at room temperature. This technology offers an efficient, cost-effective method of nanostructure fabrication, and also for magnetic nanostructres having unique morphologies, that hold great potential for reducing costs of nanostructure manufacturers. Read more
O-1155University of Louisiana at Lafayette / United States 718

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Nanostructure for Ultra-High Density Storage Media

FeRh, FePt, recording, recording media, magnetic recordings, Storage, storage media, magnetic storage, Nanostructure, hardware, Electronics, computer science, nanoparticles
- Description of the technology offer :
  
  In heat assisted magnetic recording (HAMR), FeRh-FePt composite particles are extensively used to increase thermal stability and overcome the write field limitations in both longitudinal and perpendicular magnetic recordings. Spherical nanoparticles offer magnetically isotropic media with functional advantages over conventional particles. Thus, the synthesis of spherical FeRh-FePt composite nanoparticles offers significant potential for increased magnetic storage media stability and function. This current technology offering includes methods and processes for making FeRh/FePt core shell nanostructures and their use as an ulta-high density storage media.
  
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  In HAMR, both the coercivity and saturation magnetization of FePt are lowered during the heating process.However, the lowering of saturation magnetization of FePt reduces the thermal stability of the FePt media and therefore the ability of the FePt media to maintain written data over time. By magnetically coupling FePt with FeRh, the saturation magnetization of the FeRh--FePt system is increased over that of FePt alone, resulting in an increase in the thermal stability of the magnetic recording media and solving the write-ability problem.Therefore the synthesis of FeRh and the magnetic coupling of with FePt overcomes the write field limitations in both longitudinal and perpendicular magnetic recordings. This current technology offering includes methods and processes for making uniformly spherical FeRh/FePt core shell nanostructures and their demonstrated use as an ultra-high density storage media. This technology has significant potential as a ultra-high density storage media. Read more
O-1156University of Louisiana at Lafayette / United States 619

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Low-power, high-performance flip-flop using only a single clocked transistor

transistor, flip, flop circuit, clocked
- Description of the technology offer :
  
  The clocked transistors within a flip-flop have 100% switch activity and present a huge load on the clock distribution network. If one can reduce the number of clocked transistors in a flip-flop, the clock tree will have less capacity load and hence reduce the power consumed in the clock network.. This invention provides a low power, high performance flip-flop circuit using only one clocked transistor.
  
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  Power consumption is a major concern in modern processors. Processor clock systems, consisting of flip-flops and latches, consume a large amount of power in modern processors. If one can reduce the number of clocked transistors in a flip-flop, the clock tree will have less capacity load and hence reduce the power consumed in the clock network. This will further result in reducing the number and size of the clock driving buffers, which will in turn cause a significant reduction in the power consumption of the overall system. We have invented a single-transistor-clocked flip-flop that enables minimizing of redundant switching activity, reduction of glitches at the output node, and less power consumption than current flip-flop devices. Collectively, this technology provides a low power, high performance flip-flop circuit with significant potential to increase circuit and overall system reliability, efficiency and speed. Read more

Featured innovation provider University of Alcala

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O-1188University of Seville / Spain 187

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Method for diagnosis of early Parkinson’s disease

Parkinson, Diagnosis, pharma,
- Description of the technology offer :
  
  A research group of the Andalusian Public Health System, in collaboration with the University of Seville, has developed a method for the diagnosis of Parkinson’s disease (PD) which comprises the quantification in blood, serum or plasma levels of nitro-α-synuclein nitrosylated at Tyr125 and/ or Tyr136.
  
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  There is an unmet medical need of developing new alternative biomarkers useful for the reliable diagnosis of Parkinson’s disease at early stages of the disease. The present technology relates to the use of specific antibodies against the nitronitrosylated α-synuclein residues Tyr125, Tyr136, and/ or Tyr39 in the preparation of a pharmaceutical composition for the treatment of PD. Read more
O-887UATEC - Technology Transfer Office of University of Aveiro / Portugal 969

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Innovative method for extraction of triterpenic acids

Eucalyptus, bark, triterpenic acids, ursolic/oleanolic acid, chemical extraction, fitopharmaceutics, Phyto-pharmaceutical and cosmetic industry, Pulp industry
- Description of the technology offer :
  
  The present method makes use of a simple set of unitary operations that allow an efficient, selective and economic extraction of triterpenic acids from eucalyptus bark. In addition, it makes usage of agro-industrial residues which are normally under exploited. The process can be easily integrated in the industries where the residues are abundant.
  
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  It is a process that, with a simple set of unitary operations, allows to get extracts with high triterpenic acids contents , from crude extracts of eucalyptus bark. This process can be easily integrated with existing pulp production, allowing even the subsequent exploitation of bark for energy production. Read more
O-971University of Dundee, Research and Innovation Services / United Kingdom 1375

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FMN-2: Novel Platform for the Development of Cancer Diagnostics/Therapeutics

cancer diagnostics, cancer therapeutics, tumor suppressor, cancers, ARF tumour, cell proliferation disorders, tumour supressor, tumour
- Description of the technology offer :
  
  Researchers at the University of Dundee have identified a novel and important component of a central tumor suppressor pathway. This discovery has the potential to impact upon the detection and development of novel treatments for a wide range of cancers and other disorders.
  
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  Researchers at the University of Dundee have identified a novel and important component of the ARF tumour suppressor pathway – the ARF-induced Formin-2 (FMN2) protein. Expression of the FMN-2 gene has been found to be upregulated upon induction of the ARF tumour suppressor via a mechanism that is independent of p53.
  
  Investigation has shown that elevated FMN2 expression can occur in multiple forms of cancer as well as in model tissue culture systems. Detection of elevated FMN2 levels may be useful as a cancer diagnostic and FMN2-based therapeutics may have the potential to benefit a wide range of cell proliferation disorders. Read more
O-738University of Girona / Spain 1323

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Recombinant non-genotoxic antitumor agents based on human pancreatic ribonuclease

Anticancer drug, recombinant protein, different types of cancer, multidrug resistance phenotype
- Description of the technology offer :
  
  We have engineered and developed variants of human pancreatic ribonuclease with antitumor activity. These ribonuclease variants are endowed with an NLS that directs the protein to the nucleus of the cells where they induce cell apoptosis. These novel anticancer produce pleiotropic effects on cancer cells and are appropriate to treat the multifactorial cancer disease. We are interested in licensing the products.
  
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  The ability of the human ribonuclease variants to degrade nuclear RNA is the basis of a therapeutic approach for the treatment of cancer. Our ribonucleases are non-genotoxic drugs and it is though very difficult that they may generate drug resistance phenotype onto the treated cells. In addition, its human origin warrants poor or null immunogenicity in clinical uses. Their mechanism of action is different to that of other ribonucleases that are currently being assayed in clinical trials as anticancer drugs, like onconase or other RI-evading ribonucleases. This is because our ribonucleases act by destroying nuclear RNA instead of cytoplasmatic RNA and therefore produce different effects on treated cells. Read more

Featured innovation provider University of Salamanca

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O-898Altus Formulation Inc / Canada 1971

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Novel Tamper and Abuse Resistant Delivery Technologies for Improved Patient Safety

Drug delivery, drug formulation, Abuse resistant, tamper resistant, pharmaceutical, pain
- Description of the technology offer :
  
  Altus is a full service contract development company using our patented, commercially validated drug delivery technologies to develop new 'safer to use' formulations for our clients drugs. Altus’ Intellitab technology provides the benefits of 12-24hr controlled and immediate release tablets, the differentiation and dosing flexibility of scoring and the peace of mind that comes through robust tamper resistant and abuse resistant features
  
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  Intellitab(TM) - Scored Crush, Tamper and Abuse Resistant Formulations that Prevent Dose Dumping
  
  Intellitab technologies allow, for the first time, stable scored controlled release tablets which may be broken without a change in performance – tablet pieces remain bioequivalent to the intact tablet. The hard Intellitab tablet resists breakage through chewing but if crushed and swallowed maintains controlled release with no change in peak levels of drug in the body. Further Intellitab technology robustly resists drug extraction in a range of solvents and liquids ,whether hot or cold, and prevents injection and euphoria through inhalation or insufflation.Immediate release tablets that prevent injection and the aims of insufflation are also available.
  
  By mitagating medication error, deliberate or inadvertant, Intellitab makes medications safer to use for the legitimate patient and protects those attempting non-medical use.
  
  Products approved on the Intellitab platform have obtained new class labeling from FDA based on their PK performance post breaking. Manufacturing utilises conventional equipment and processes to minimize cost of goods allowing the most appropriate price point for your drug.
  
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O-1159University of Louisiana at Lafayette / United States 597

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Smart card read / write controller and process

Smart card, card, controller, read, write, magnetic strips
- Description of the technology offer :
  
  Microcontroller to read/write data from/to a plurality of tracks contained on magnetic strip value card. The microcontroller device includes an input capture port for storing data read from the card, and wherein the microcontroller device continually poles the input capture port for an event to occur. This invention integrates the entire read/write system - the controller design, the steps for processing the signal, and writing to the stripes - into one single chip that accounts for varying swipe-speed with time
  
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  This novel invention takes advantage of the development in integrated circuits microcontrollers, and the development in hard disk technology namely magnetoresistive read heads. A debit card read/write controller. The controller comprises a microcontroller device, a read only memory, a dynamically random access memory and a read/write head for reading and writing onto a magnetic card media contained on a magnetic striped card. The microcontroller device includes an input capture port for storing data read from the card, and wherein the microcontroller device continually poles the input capture port for an event to occur. This invention integrates the entire read/write system - the controller design, the steps for processing the signal, and writing to the stripes - into one single chip that accounts for varying swipe-speed with time Read more
O-380BIOPOLIS, S.L. / Spain 3114

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Probiotic Bifidobacterium bifidum against Helicobacter pylori

Biotechnology, microbial, Bifidobacterium bifidum, probiotics, Helicobacter pylori
- Description of the technology offer :
  
  Novel probiotic Bifidobacterium bifidum CECT7366, eradicating pathogenic bacterium Helicobacter pylori.The use of probiotic Bifidobacterium bifidum CECT7366 is a potentially promising tool to prevent H. pylori infections. The research has revealed that strain B. bifidum CECT7366 is a probiotic bacterium with functional activity against H. pylori in vitro and even in vivo in a murine infection model.
  
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  Currently, antibiotic-based treatment of H. pylori infection is neither sufficient nor satisfactory;
  the most successful treatments reaching 75 to 90% eradication rates. Alternative or complementary approaches to antibiotic therapy are being assessed. In this respect, the use of probiotics is a potentially promising tool to prevent H. pylori infections. BIOPOLIS selected a probiotic strain that hampers H. pylori growth in vitro and identified the nature of the metabolites responsible for this inhibitory activity. We also used a murine model to demonstrate its capacity as well as its toxicological innocuousness. Read more
O-448Ciber-BBN / Spain 1922

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New procedure for obtaining a biomaterial with metallic coating - aplicattions in Implants, orthopaedic devices and prosthesis

Biomaterials, metallic coatings, orthopaedic devices, implants,
- Description of the technology offer :
  
  The present invention refers to a procedure for obtaining a biomaterial with metallic coating, by means of a metallurgic method comprising the immersion of a metallic substrate, based on titanium, in a melted alloy of silicon and aluminium. Besides, the present invention refers to the use of this biomaterial for medical applications.
  
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  - Specificity and effectiveness to obtain a biomaterial based in a titanium substrate with a metallic coating.
  - Hardness and ductility for the biomaterial.
  - Coating is persisten to corrosion, and biocompatible.
  - Thermal treatments in the procedure allow relaxing the residual tensions and increases the thickness of the coating. What significantly affects the superficial properties and the biological response. Read more

Featured innovation provider University of Dundee

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O-1049University Pablo de Olavide / Spain 1054

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Novel multi-screen device for animal experiments in neuroscience research

neurophysiology, neurophysiological, neuropsychology, neuropsychological, Neuroscience, animal experiments, neuroscientific, laboratory animals, metacognition, animal learning
- Description of the technology offer :
  
  This invention refers to a novel multi-screen device for studying self-learning and the capacity for self-regulation of self-learning in mice, and even in humans, by means of classic and operating conditioning. The device comprises a virtual environment where the subject to be studied is immersed, making it possible to visualise elements in touchscreens, using a software and as a function of mental impulses, in a fast and flexible manner, without requiring mechanical handling.
  
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  • This invention makes it possible to explore the neuropsychological processes in the subject under study through the introduction of objects in touchscreens, as a function of its mental impulses. Thus, animals can, for the first time, interact conceptually with a virtual learning interface.
  • Using the device, the presentation of stimuli can be changed in a flexible manner, through the use of software, and experiments can be designed by means of animal interaction with the screens and the virtual environment.
  • In addition to exploring the behaviour of laboratory animals, this device can be used to explore that of human beings, by changing the scale, in an immersive environment of virtual reality. Thus, perception studies, therapies and ludic applications of virtual games can be performed.
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O-1187University of Seville / Spain 309

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Method for diagnosis of severity of Parkinson’s disease

Redox, Parkinson, halogenation, Diagnosis, Kit
- Description of the technology offer :
  
  A research group of University of Seville and medical Andalusian health service, have recently demonstrated that there is an altered Redox state in serum of patients with early Parkinson’s disease, characterized by halogenative and nitrosative stress, together with anomalous nitrosylation of serum alpha-synuclein.
  
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  Protein and amine halogenation is a type of oxidative stress induced by phagocytic over-stimulation,
  and its role in Parkinson’s disease has not been discerned. Researchers propose the need for a development of a easy kit for rapid measuring of AOPP in serum of patients, which would allow following-up each patient in order to discern severity of the disease. Read more
O-1175Syncoda Technologies / United States 295

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A portfolio of 200+ worldwide patents/applications covering SIM-card-based 2.4 GHz wireless mobile payment technologies allowing E-wallet capability addon to conventional cell phones

wireless, mobile payment, payment technologies, online payment, payment, smart phones, cell phones, SIM card, mobile credit cards, Mobile banking, mobile ticketing
- Description of the technology offer :
  
  Pioneer High-Frequency (e.g., 2.4 GHz) Mobile Payment Technology. Faster, More Secure Than Other Technologies (e.g., NFC). SIM-Card Based. Complete patent portfolio for licensing/sale. Complete technology transfer. Joint ventures/productions possible. Low cost: a few dollars to replace the SIM card. Complete package including 200+ Worldwide Patents/Applications directed to this technology
  
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  -Plug-and-play technologies (e.g., SIM-Card-Based Mobile Payment Add-On Capabilities)
  -Instead of getting a new phone with mobile payment capability, users can simply replace a SIM card, or plug in an add-on card, to add such capability to existing mobile phones
  -Fast Deployment on the user side: only need to replace the SIM card or add a sticker to the SIM card;
  -Fast Deployment on the POS side: no need to change the billing system; does not affect other applications
  -Achieving Range Control with Magnetic Field
  -Fast Data Flow with RF (e.g., 2.4 GHz)
  -Extra Layer of Security
  Read more
O-444CIBER-BBN / Spain 1584

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New micro-chamber device for cellular culture monitoring by nuclear magnetic resonance

NMR, cell culture, diagnostics, imaging, cellular culture, magnetic resonance, NMR, image techniques, drugs, nanoparticles, biological factors
- Description of the technology offer :
  
  The present invention comprises a micro-chamber device for cell culture allowing longitudinal long-term monitoring of the cellular system by NMR and other image techniques. Image analysis and metabolic studies can be performed. Effect of active agents, such as drugs, nanoparticles or biological factors, can be assessed. By using it, a better knowledge of physiological and pathological conditions will be acquired, helping for diagnosis and therapy.
  
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  Its made of biocompatible materials in which longitudinal long-term studies of cell cultures can be performed. It's of appropiate design and size for NMR equipment commercially available. It's a transparent material, therefore also useful for other microscopic technique. It has a diffusion system for the uniform distribution of cells. You can control physico-chemical properties of the culture by optic fibre sensors for pH, pO2, pCO2,pNO, or pSH2. High resolution and easily handle by users. Read more

Featured innovation provider IK4-IKERLAN

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O-1100Biomedical Engineering Research Centre / Spain 705

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Biofeedback systems for urinary incontinence treatment

Bioengineering, hospital, medical devices, clinicians, urologist, urology, urinary incontinence, urinary
- Description of the technology offer :
  
  A "Biofeedback for pelvic floor training" fully functional and competitive has been validated by clinical staff specialized in urology and tested on voluntary giving excellent results. The developed system has an added value in relation to other tele commercial solutions from a usability standpoint and also provides more versatile services personalized to the patient treatment. The system software has a simple user interface, with a friendly communication with the other stages transparent to the user. Also, the application includes numerous options that allow clinicians to make your task easier and faster.
  
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  The advantage of this new system compared to others, is the study of the signal from the abdomen to monitor whether the exercise is being performed properly. In addition to the signal displayed, it is used as a criterion for evaluating the quality of the exercises per-formed, thus fulfilling another requirement. Read more
O-1185CELEROMICS TECHNOLOGIES, SRL / Spain 471

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Automated Cell Counter for microscopes. Our system plugs to any laboratory microscope and is able to measure cell density or confluence in counting chambers, petri dishes, well plates, etc.

Microbiology, biology, laboratory, microscopy, microscope, microscopes, cell counter, molecular biology, genetics, counting chambers, petri dishes, well plates, Cell, Biotechnology
- Description of the technology offer :
  
  Automated Cell Counter for microscopes. Our system plugs to any laboratory microscope and is able to measure cell density or confluence in counting chambers, petri dishes, well plates, etc. No disposable or maintenance is required, no need to sacrifize cells to perform cell count, minimizing cell handling and eliminating cell contamination.
  
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  Our systems plug to any laboratory microscope.
  
  It is able to count from 1 to 1000 microns in particles analyzed with a single device.
  No need for disposable material or reagents : savings 500-2000 EUR /year.
  It is able to count inside the bioreactor : no need to open the container / sacrifize the culture to perform the count. Read more
O-1181Innovation Department - Hospital Clinic Barcelona / Spain 546

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New Test for the Prognosis of Chronic Lymphocytic Leukemia (CLL)

Healthcare, prognosis, Diagnosis, diagnostic test, diagnostics, leukemia, clinical protocols, epigenetics, Biomarkers, PCR, qPCR, oncologists, oncology, hospitals, medical centres
- Description of the technology offer :
  
  The present invention aims at developing a new diagnostic test in CLL for a better patient stratification into prognostic groups
  • This new tool is able to classify CLLs into 3 new prognostic groups: MBC-like, intermediate, and NBC-like, using only 5 epigenetic biomarkers
  • After 10 years only 20% of the patients from the MBC-like group, 43% from the NBC-like group, and 100% from the NBC-like group will need treatment
  • This stratification will allow a better management of the patients improving their quality of life and to rationalise the health care expenditure
  
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  The current classification of M-CLL (mutated) and U-CLL (unmutated) is not used in clinical protocols to decide upon patient treatment and follow-up. The possibility of a better diagnosis and prognosis of CLL would be very useful for the proper management of the patients.
  Follow-up checks could be done less frequently improving the quality of life of those patients that have a better prognosis, such as the MBC-like group.
  This test will allow to:
  - Improve the quality of life of CLL patients
  - Improve management strategies that are more adjusted to the biology of this disease
  - Reduce the health care costs Read more
O-848UATEC - Technology Transfer Office of University of Aveiro / Portugal 1296

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Developed New Scintillating Optical Fiber Dosimeter

Dosimetry, radiotherapy, cancer, optical fiber, security, hospitals, clinics, medical equipment
- Description of the technology offer :
  
  A group of researchers at the University of Aveiro has developed a dosimeter for low energy and low dose rates. The invention aims to monitor the dose levels, applicable to the field of nuclear physics and medical physics, particularly in radiotherapy. This device has also application in the dose control and monitoring in imaging systems based on ionizing radiation and in industrial control and monitoring.
  
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  The invention aims to monitor the dose levels, applicable to the field of nuclear physics and medical physics, particularly in radiotherapy. This device has also application in the dose control and monitoring in imaging systems based on ionizing radiation and in industrial control and monitoring.The advantages of this technology in relation to existing technologies, include the fact that it allows the application in brachytherapy modalities for which other devices are not sensitive enough or do not meet the requirements for in-vivo and real time dosimetry. Read more

Featured innovation provider University of Almeria

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O-1177University of Burgos / Spain 6

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Optimization and Rationalization Systems for logistics operations

transport, logistics, Orders, Routes, optimization, Transporte, Logística, Pedidos, Optimización, Rutas
- Description of the technology offer :
  
  Development of route optimization systems for companies or entities interested to solve their transportation planning (or branch customer delivery, collection of suppliers, etc..), Thus helping to making responsible decisions of different entities.
  Many of the problems that are analyzed and solved are related to complex logistics operations: mainly routing problems, location, storage, etc.. And others which combine aspects of the above.
  
  The developed systems offer a user-friendly visual environment, easily manageable. Basically manages the following:
  - Data entry, which can be done by file or interactively
  - Optimization algorithms to suggest the most appropriate solutions
  - Data output: full paths sheets with all information
  - A GIS (Geographic Information System) to more easily visualize the locations (warehouses, customers, suppliers, etc..), Roads, and routes learned
  
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  - Helps decision making
  - Analyze and solve complex logistics operations: routing problems mainly, location, storage, work schedules, etc.... Read more
O-412CIBER-BBN / Spain 1560

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Optimized histological method for the preservation of epitopes and cellular architecture.

histological methods, vertebrate tissues,
- Description of the technology offer :
  
  Its a new method for the optimal preservation of the morphology and the maintainance of the reactive properties of vertebrate tissue in histological samples. It represents a good alternative to classi histological methods usually used for studying vertebrate embryogenesis in order to solve such common problems as lability of epitopes or as processin samples where rigid tissues intercalates between soft ones.
  
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  This invention develops an optimized new method for the histological and histochemical preservation of tissue. It is compatible with any staining method. The optimization with respect to the present techniques is achieved by the combination of fixing and inclusion conditions and the use o the appropiate chemicals and materials for fixation and inclusion, allowing a very high preservation of the morphology and reactive properties of the tissue. Read more
O-1160University of Louisiana at Lafayette / United States 984

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A Method for Room Temperature Preparation of Titania Coated Magnetic Nanospheres and other Nanostructures

Titania, Titanium dioxide, nanoparticles, magnetic, ferrite, micelle, photocatalytic; germicidal
- Description of the technology offer :
  
  Titanium dioxide (titania) is one of the world's most demanded chemicals because of its high versatility of use. Researchers at the University of Louisiana at Lafayette have developed a method for preparing composite, nonmixed nanospheres comprised of a nickel ferrite core and having a titanium dioxide (titania) shell with photocatalytic and germicidal activity. This technology uses a proprietary reverse micelle chemistry methodology that does not require expensive machinery or elevated temperatures. (Ref US7504130, US7964013, US8197890, US7635518).
  
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  Permits 100% titania availability and minimizes nonavailable, internal titania waste (in contrast to mixed
  titania / ferrite composites);
  • Modified reverse micelle chemistry is performed at room temperature and without the need for
  expensive machinery;
  • Permits removal of titania nanoparticles from liquid solutions and environmental sources (a current EPA concern) via magnetic manipulation;
  • Demonstrated germicidal and photocatalytic coating for industrialand biomedical uses;
  • Reusable means of decontamination, chemical reduction (N2 & CO2) and catalysis;
  • Other preferred applications of this technology include custom shaped magnetic nanorods
  (US8197890, US7635518) and nanospheres for ultrahighdensity storage media (US7964013). Read more
O-1180Innovation Department - Hospital Clinic Barcelona / Spain 473

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Tolerogenic dendritic cells and their use in cell therapy for the treatment of Crohn’s disease

inflammatory diseases, crohn’s disease, Cellular therapies, Cell therapy, inflammatory, immunosuppressive agents, immune system, immunology, autoimmune disorders, bioscience
- Description of the technology offer :
  
  We have developed a cellular-based therapy for the treatment of human chronic inflammatory diseases, in particular for Crohn’s disease patients. Our innovative protocol generates tolerogenic dendritic cells able to attenuate inflammatory responses. This technology can be extrapolated to several human diseases.
  
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  We described a clinical applicable method to generate tolerogenic dendritic cells by combination of immunosuppressive agents and growth factors. This specific combination yielded cells with powerful anti-inflammatory properties being able to inhibit the activation of the immune system. Read more

Featured innovation provider University of Lleida

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O-1173Tecnológico de Monterrey / Mexico 8

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New process to obtain hydroxyapatite moulds derivated from mammals for biomedical purposes (applications in biomaterials, implants, prosthesis, biocements, biogels)

biogel, biocements, implants, Biomaterials, Prosthesis, bones, biomedical, Healthcare
- Description of the technology offer :
  
  This technology describes the process to transform the bovine bones, in order to obtain natural hydroxyapatite, with this biomaterial are manufactured biocompatible implants with the support of CAD software and CAM machines, also are produced biocements and biogel to cover fissures at the human bone.
  
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  The innovation of this technology is the medium that we obtain the raw material and the transformation process. The process allow us obtain structures with similar porosity of the human bones, with that characteristic, the integration occurs in a low period of time.
  The easy manufacture allows make different geometry also complex geometry to development prosthesis. Read more
O-1126Jagiellonian University / Poland 897

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New drug candidates for treatment of neuropathic pain and epilepsy.

neuropathic pain, drugs, Drug, antiepileptic drugs, drug candidates, epilepsy, MEDICAL, neurological disorders, Neurological, neurology, neurologist, nervous system, pharmaceutical
- Description of the technology offer :
  
  The subject of this in-licensing offer is a number of drug candidates for treatment of epilepsy and/or neuropathic pain. The group of 80 molecules, containing two in late preclinical phase, have been developed by at the Jagiellonian University Medical College. The two most active molecules have been tested in an array of pre-clinical assays; their efficacy has been evaluated and confirmed in vivo. Tested compounds are effective in drug resistant refractory epilepsy and neuropathic pain of various etiology.
  
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  Despite the large number of available antiepileptic drugs, approximately 30% of patients fail to control seizures, and among those experiencing partial seizures (simple, complex, and secondarily generalized) the percentage is even higher at around 40%. Such a form of epilepsy is called drug resistance. One reason for the wide prevalence is the problem of insufficient efficacy of the currently available antiepileptic drugs. Also neuropathic pain in many cases is unable to control with use of currently used drugs. One of the possible reasons is that there are many mechanisms for the formation of the peripheral and central neuropathic pain, which frequently are still poorly known. Neuropathic pain is a serious clinical problem which affects up to 7 ‐ 8% of the population. Compounds included in the offer meet requirements for new, innovative drugs efficient in epilepsy and neuropathic pain cases which are still unmet medical needs (particularly drug resistant epilepsy and uncontrolled neuropathic pain – frequently of unknown etiology). Read more
O-1179Innovation Department - Hospital Clinic Barcelona / Spain 495

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New method for the diagnosis and clinical evolution of heart failure patients

myocardial infarction, heart transplantation, Heart failure, heart attack, heart transplantation, cardilogists, cardiology, infarction, strokes, clinical, coronary, Biomarkers, medical doctors, health system, prognosis, Diagnosis, primary care
- Description of the technology offer :
  
  New method for the diagnosis and prognosis of heart failure based on the measure of one soluble protein in serum. The method allows the stratification of heart failure patients and provides reliable information to help cardiologists and general practitioners in decision making for the initiation of new medical treatment, determining the efficacy of said medical regimen or recommending heart transplantation.
  
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  The current methods for the diagnosis and prognosis of heart failure in serum do not allow the stratification of heart failure patients with statistically significant results because they lack the specificity required. This new method is based on the measure of one stable protein in serum, that is differentially expressed in control and people suffering from heart failure. The stability of the protein in serum allows its comfortable and reliable measurement. Read more
O-1178University of Burgos / Spain 0

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Urban transport Rationalization

Urban Transport Rationalization and Optimization
- Description of the technology offer :
  
  A computer program that helps urban transport planning, in order to optimize the level of service provided to users. In this case the level of service is measured by waiting times at bus stops and transport.
  
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  - Using pseudo-optimal algorithms and optimal ad-hoc adapted to this kind of problems
  - Integration of them in GIS to visualize more easily the streets, stops and routes learned
  - Consideration of several targets simultaneously
  - Analysis of nooks, unnecessary stops and their influence on the level of service Read more

Featured innovation provider IRIS Research & Development

About IRIS Research & Development

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O-1171University of Burgos / Spain 723

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New cross-linked aramid polymers (aramids) that shows improved properties: electrical insulation, thermal, stability, and/or mechanical properties while maintaining ease of processing

Aramid, aromatic polyamides, high performance fibers, crosslinked fibers, crosslinked aramids
- Description of the technology offer :
  
  The new cross-linked aramid polymers have shown improved properties, in particular, electrical insulation, thermal, stability, and/or mechanical properties while maintaining ease of processing. Further, the properties shown by the new cross-linked aramids of the invention render the product especially suitable for advanced technological applications. The crosslinking can be done without investment in nowadays aramid fiber industrial production facilities.
  
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  Crosslinking of aramid fibers by conventional production technologies (wet, dry, and dry-jet wet spinning). The crosslinking of armid fibers will render materials with even higher fire, mechanical and electrical-isolation performance. Read more
O-1172HP Ingredients / United States 334

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Composition of Labdane Diterpenes extracted from andrographis Paniculata, useful for the Treatment of autoimmune diseases and Alzheimer Disease by activation of the PPR-Gamma Receptors

neurology, Alzheimer, immune, immunology, immune health, autoimmune, Autoimmune diseases, nutraceuticals, brain health
- Description of the technology offer :
  
  ParActin® (14-NEO-ANDRO) Health Natural Pain Reliever. Composition of Labdane Diterpenes extracted from andrographis Paniculata, useful for the Treatment of autoimmune diseases and Alzheimer Disease by activation of the PPR-Gamma Receptors.
  
  HP Ingredients is dedicated to providing cutting edge, science based nutraceutical that addresses cholesterol, blood glucose control, weight management, joint health, andropause, and healthy aging.
  
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  A randomized, double blind, and placebo-controlled study in patients with rheumatoid arthritis (RA) was performed. 100mg of Paractin® were administered three times a day for 14 weeks, after a 2-week washout period to 60 patients with active RA. Patients were allowed to take prednisone or chloroquine (stable doses). MTX was administered to all patients as standard treatment.
  
  On day 1, and at the end of week 2, week 6, week 10, and week 14 the following exams were performed:
  1. Evaluation of the number of inflammatory and painful joints.
  2. Evaluation of pain by the patient utilizing the Visual Analog Scale (VAS).
  3. Improvement in the evaluation of health quality of life questionnaires
  4. Duration of morning rigidity.
  5. Global evaluation of symptoms by the patient and researchers.
  6. Global evaluation of the tolerance by the patient and researchers.
  
  Paractin® Group showed significant diminishing in:
  1. number of swollen joints (Paractin 9 vs Placebo 13)
  2. total grade of swollen joint (Paractin 11 vs Placebo 16)
  3. total grade of tender joints (Paractin 14 vs Placebo 17)
  4. HAQ (Paractin 19 vs Placebo 24)
  5. reduction of rheumatoid factor (Paractin 119 vs Placebo 130)
  6. reduction in IgA (Paractin 293.7 vs placebo 335) Read more

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5TH NEW PRODUCT DEVELOPMENT AND INNOVATION MANAGEMENT

3rd Annual Alliance Management for Open Innovation in Pharma

XXIV ISPIM Conference, 16-19 June 2013, Helsinki, Finland: Innovating in Global Markets:

The 6th ISPIM Innovation Symposium – Innovation in the Asian Century

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amination, amine, Chiral, chiral amine, petrochemical, fine chemical, agrochemicals, pharmaceutical compounds, olefins, aryl, alkene, esters, asymmetric allylic

Nanorods, dendritic, magnetic nanostructures, nanoparticle, Nanostructures, Nanowires, nanotubes, nanomanufacturing, electrochemistry, chemical vapor deposition, supercapacitors, chemical, Chemistry

FeRh, FePt, recording, recording media, magnetic recordings, Storage, storage media, magnetic storage, Nanostructure, hardware, Electronics, computer science, nanoparticles

transistor, flip, flop circuit, clocked

Parkinson, Diagnosis, pharma,

Eucalyptus, bark, triterpenic acids, ursolic/oleanolic acid, chemical extraction, fitopharmaceutics, Phyto-pharmaceutical and cosmetic industry, Pulp industry

cancer diagnostics, cancer therapeutics, tumor suppressor, cancers, ARF tumour, cell proliferation disorders, tumour supressor, tumour

Researchers at the University of Dundee have identified a novel and important component of a central tumor suppressor pathway. This discovery has the potential to impact upon the detection and development of novel treatments for a wide range of cancers and other disorders.

Anticancer drug, recombinant protein, different types of cancer, multidrug resistance phenotype

Drug delivery, drug formulation, Abuse resistant, tamper resistant, pharmaceutical, pain

Smart card, card, controller, read, write, magnetic strips

Biotechnology, microbial, Bifidobacterium bifidum, probiotics, Helicobacter pylori

Biomaterials, metallic coatings, orthopaedic devices, implants,

neurophysiology, neurophysiological, neuropsychology, neuropsychological, Neuroscience, animal experiments, neuroscientific, laboratory animals, metacognition, animal learning

Redox, Parkinson, halogenation, Diagnosis, Kit

wireless, mobile payment, payment technologies, online payment, payment, smart phones, cell phones, SIM card, mobile credit cards, Mobile banking, mobile ticketing

NMR, cell culture, diagnostics, imaging, cellular culture, magnetic resonance, NMR, image techniques, drugs, nanoparticles, biological factors

Bioengineering, hospital, medical devices, clinicians, urologist, urology, urinary incontinence, urinary

Microbiology, biology, laboratory, microscopy, microscope, microscopes, cell counter, molecular biology, genetics, counting chambers, petri dishes, well plates, Cell, Biotechnology

Healthcare, prognosis, Diagnosis, diagnostic test, diagnostics, leukemia, clinical protocols, epigenetics, Biomarkers, PCR, qPCR, oncologists, oncology, hospitals, medical centres

Dosimetry, radiotherapy, cancer, optical fiber, security, hospitals, clinics, medical equipment

transport, logistics, Orders, Routes, optimization, Transporte, Logística, Pedidos, Optimización, Rutas

- Helps decision making - Analyze and solve complex logistics operations: routing problems mainly, location, storage, work schedules, etc.... Read more

histological methods, vertebrate tissues,

Titania, Titanium dioxide, nanoparticles, magnetic, ferrite, micelle, photocatalytic; germicidal

inflammatory diseases, crohn’s disease, Cellular therapies, Cell therapy, inflammatory, immunosuppressive agents, immune system, immunology, autoimmune disorders, bioscience

We described a clinical applicable method to generate tolerogenic dendritic cells by combination of immunosuppressive agents and growth factors. This specific combination yielded cells with powerful anti-inflammatory properties being able to inhibit the activation of the immune system. Read more

biogel, biocements, implants, Biomaterials, Prosthesis, bones, biomedical, Healthcare

neuropathic pain, drugs, Drug, antiepileptic drugs, drug candidates, epilepsy, MEDICAL, neurological disorders, Neurological, neurology, neurologist, nervous system, pharmaceutical

myocardial infarction, heart transplantation, Heart failure, heart attack, heart transplantation, cardilogists, cardiology, infarction, strokes, clinical, coronary, Biomarkers, medical doctors, health system, prognosis, Diagnosis, primary care

A computer program that helps urban transport planning, in order to optimize the level of service provided to users. In this case the level of service is measured by waiting times at bus stops and transport.

Aramid, aromatic polyamides, high performance fibers, crosslinked fibers, crosslinked aramids

Crosslinking of aramid fibers by conventional production technologies (wet, dry, and dry-jet wet spinning). The crosslinking of armid fibers will render materials with even higher fire, mechanical and electrical-isolation performance. Read more

neurology, Alzheimer, immune, immunology, immune health, autoimmune, Autoimmune diseases, nutraceuticals, brain health

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Registered user

- Helps decision making
- Analyze and solve complex logistics operations: routing problems mainly, location, storage, work schedules, etc.... Read more