Cutting-edge technologies browser

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O-1252Universidad de Murcia / Spain 0

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Compound with anticoagulant activity in the field of new antithrombotic

antithrombotic, Anticoagulant, heart attacks, blood coagulation
- Description of the technology offer :
  
  The invention is a molecule called D-myo-inositol 3, 4, 5, 6 tetrakisfosfato (hereinafter TMI), with a potential therapeutic value in the prophylaxis / prevention and / or treatment of thromboembolic diseases, particularly arterial thrombosis and heart attacks; it will be used to recover the antithrombin activity in cases of patients with antithrombin deficiency or treatments of diseases associated with increased blood coagulation.
  
  TMI actives antithrombin in the presence of heparin from 10 to 20 percent, which is considered very important. With all this, thrombin activity (which is responsible for the fibrinogens becomes fibrin and therefore clot forms) is inhibited.
  
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  Among the factors that encourage blood clotting, thrombin is playing a more important role. An excess of thrombin uncontrolled may result in clots that lead to severe illness or even death. It is desired to regulate the thrombin molecule so this is achieved by activating antithrombin.
  
  There are several compounds that already activated it, usually from polysaccharides although, the most important is heparin, which by binding to antithrombin complex creates an inhibitor that increases the efficiency of the inhibitory effect on thrombin.
  
  The problem is that heparin has undesirable side effects. This new molecule is not derived from polysaccharides and it has an affinity higher than the affinity of heparin.
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O-1251Gaiker, Technological Centre / Spain 0

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Development of fluorescencent quantitative immunochromatography strip tests for human and animal health, food safety and environmental quality analysis

Inmunoassay, strip test, Lateral Flow, Immunochromatography, Point-of-Care, Point-of-Test, fluoresce
- Description of the technology offer :
  
  Highly sensitive lateral flow strip tests as rapid, easy-to-use, low-cost and portable biodetection systems to be implemented as quantitative analytical tools in human and animal health, food safety and environmental quality .
  
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  Lateral-flow immunoassays (LFIAs) represent a well-established technology appropriate for use in a wide variety of point-of-care (POC) or field-use applications. However, this technology has not been applied much where very sensitive results are required. The utility of these tests is enhanced by the ability to determine analytes at lower concentrations than standard lateral flow. We offer an innovative technology with an improved limit of detection compared to a conventional lateral flow assay. Further, the generated fluorescence can be measured for a quantified result. Read more
O-1237anonymous company / Saudi Arabia 0

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A desalination concept which combines the working principles of conventional steam ejectors and those of evacuated tubes to result into a solar thermal ejector for the purpose of reducing energy and equipment to save desalination costs.

desalination, solar termal, ejector, small scale, low tech desalination
- Description of the technology offer :
  
  We propose here an open desalination concept which uses solar thermal energy and simulates the rain cycle to reduce energy in which further the steam is forced into the diverging section of the solar thermal steam ejector causing it to expand and in which the cross sectional area of the ejector outlet is suitably larger than the cross sectional area of the ejector throat which cause the steam to attain high velocities reaching the speed of sound as well as generate shock waves which increase the mass flow of the steam forcing it into the steam line without mechanical pumps thus reducing the amount of equipment and hence also reduce energy and equipment use to reduce overall desalination costs.
  
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  Existing desalination plants operate at a low efficiency of around 10-20%. This is mainly because the system was designed back in the 1950’s when energy supply was readily available and water shortage was not so severe. Their design is LINEAR and rely on increasing their size for more output hence their low efficiency. Around 80% of the seawater is rejected to the sea at high temperature and hence a considerable energy loss. Large intake structures, boilers, evaporators, pressure reducers, pumps and other equipment are therefore needed to handle this large amounts of seawater. This increases the installation, processing, operation and maintenance costs which increases the overall cost of the process.
  
  Solar energy is available for most of year in tropical areas facing water shortages. This because existing desalination equipment cannot make direct use of solar energy shortages. The solar thermal ejector absorbs and retain solar thermal heat to overcome this problem. Also the internal flow is vortical and NONLINEAR and relies on internal shape nozzle constrictions rather than increasing external equipment size. Read more
O-921CIBER-BBN / Spain 1238

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New lab-on-chip cell culture device: to be use in high throughput analysis of cell cultures, allowing the study of their growth and response to the environment (culture condition, culture medium, drugs, etc)

Substrate, screening, Cell, Culture
- Description of the technology offer :
  
  The present invention refers to an encapsulated device (lab-on-chip) useful to study cell cultures. It is preferably made of a plastic material where several culture wells are located. Bottoms of wells are covered with a gelled material, differing from mechanical properties in each well. The objective of the invention is the production of high throughput analytical systems capable of studying the cellular response depending on the gelled substrate rigidity.
  
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  It is known that the mechanical properties of the substrates have an important effect in the behavior and development of cell cultures. Among them, rigidity is especially relevant. Therefore, research groups in this field increasingly need available samples on substrates with different rigidity. To date, such experimental devices have been individually developed by researchers for their own necessities, for single use and lacking of general application. Therefore, there is a necessity of developing high throughput analytical systems to, easily and quickly, characterize cell culture response to different rigidity of substrates. The present invention is aimed at fulfilling this necessity.
  
  A lab-on-chip device has been developed to be use in high throughput analysis of cell cultures, allowing the study of their growth and response to the environment (culture condition, culture medium, drugs, etc.) depending on the substrate rigidity. This device comprises a gel maker with, at least, two entry channels, a mixer to create a mixing gradient, exit channels connected to a multi-well culture chamber, allowing gels differing from rigidity to be deposited, as substrate, in different wells. The culture chamber also comprises entry and exit channels for culture medium, cells, and agents (biological factors, drugs, etc.) to be added to the wells. This invention comprises the device itself, the culture method using this device, and the manufacturing process of the device. Read more

Featured innovation provider University of Alcala

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O-1221UNAM / Mexico 643

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Bioplastics production derived from citric pectin and its nanocomponents using nanoclay and nanosilice.

packing, plasticizer, plastic films, plastic waste, plastics, Plastic, bioplastics, food packaging, pharmaceutical packaging, packing, nanoclay, citric pectin
- Description of the technology offer :
  
  Production of bioplastics derived from citric pectin and its nanocompounds using nanoclay and nanosilice. Helps to reduce pollution by reducing plastic waste because at the time they're discarded they degrade into their original components returning to the environment. The plastic films obtained are optically transparent with 2% g/g of nanoclays which can be alter as needed.
  
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  Resolves two fundamental environment issues, first, eliminates the need for petroleum to fabricate plastics, and second, eliminates a serious environmental issue which is the contamination to our planet. Final product can be used as a replacement to plastics. It is resistant, transparent, flexible and organic. It degrades in less time than regular plastic; while some companies have developed similar technologies with a degradation time of 180 days, this technology only takes form 0 to 60 days. Read more
O-1244Universidad de Murcia / Spain 107

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New type of optical microscope which allows the acquisition of three-dimensional images of transparent samples in real time.

microscope, optical microscope, microscopy, optical microscopy, microscopic techniques, microscopic images, biology
- Description of the technology offer :
  
  In optical microscopy is often necessary to work with transparent samples that can not be determined without markers which may limit the functional integrity of the cells. Some classical contrast microscopy techniques allow partial visualization without markers. However, in many cases, for example, in studies of cell motility and developmental biology, it is useful not only visualize but to obtain full three-dimensional information of the sample. The classical techniques do not allow this. In recent years, a variety of techniques have appeared trying to solve this problem but with highly complex instrumentation or sophisticated image acquisition and processing methods that make difficult to foresee widespread use.
  
  The new optical microscope has low instrumental complexity and can be implemented in conventional
  
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  This technology allow to obtain easily full real time three-dimensional information of the sample. The classical microscopic techniques do not allow this or can do so with great difficulty. The method has low instrumental complexity and can be implemented in conventional optical microscopes as an accessory. Read more
O-1238Gaiker, Technological Centre / Spain 130

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Flow cytometric monitorization of cell viability and lipid accumulation in microalgae cultures

culture monitorization, cell viability, flow citometry, Microalgae lipid content
- Description of the technology offer :
  
  A simple and rapid method for determining cell viability and intracellular lipid content in a microalgae culture. Flow cytometry simultaneously measures autofluorescence of the pigments present in microalgae and the fluorescence of individual cells stained with specific dyes. By means of this technology is possible to distinguish live and dead cell populations, the health of a microalgae culture and monitor the lipid accumulation in microalgae cells.
  
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  Compared with conventional methods, generally complex, time-consuming, labour-intensive and that involves toxic solvents, analysis by flow cytometry allows a simultaneous and cost-effective technique for elucidate in real time the state of a microalgal culture. These characteristics involve the possibility of taking decisions on process control strategy during the microalgal growth. Read more
O-1248University of the Balearic Islands - Technology Transfer Office / Spain 69

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Input bandwidth adjustment system for time-interleaved analog-to-digital converters

TI ADC, bandwidth mismatch, mixed-signal calibration, digital calibration
- Description of the technology offer :
  
  Manufacturing process variations alter the electrical characteristics of any integrated circuit. Because of that, new systems tolerant to these variations are topics of active research. Specifically, those focused on time-interleaved analog-to-digital converters (TI ADCs), where bandwidth mismatch between parallel input sampling switches reduces their maximum attainable linearity.
  
  A new analog input bandwidth adjustment system is launched here. This system can be used to equalize the input bandwidth of each parallel input sampling switch of TI ADCs.
  
  The proposed calibration system for TI ADCs could be interesting for companies in the electronics sector, and specially for those focused on the design and implementation of analog and mixed-signal integrated circuits willing to commercially develop this system in exchange for patent licensing and technical cooperation.
  
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  The proposed analog adjustment system together with existent digital detection techniques make up a cutting edge mixed-signal calibration system, as an alternative to conventional all-digital calibration ones. Such system fully exploits the robustness of a digital detection and the simplicity of the proposed analog correction hardware. So, the analog input bandwidth adjustment is ready to replace conventional adaptive digital calibration filters commonly used to correct bandwidth-mismatch-related errors. Read more

Featured innovation provider University of Salamanca

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O-1249UATEC - Technology Transfer Office of University of Aveiro / Portugal 91

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Ceramic slurry with the incorporation of eggshell waste

egg, eggs, eggshell waste, egg derivatives, ceramic, ceramics, waste, residues
- Description of the technology offer :
  
  The main goal of present invention is the industrial application of eggshell waste avoiding all the environmental problems of deposing it in a landfill. The advantage of this process is showing that is possible to enlarge the application fields of the residue substituting traditional raw material, calcite, for a low cost material. The University is looking for slurry ceramic preparation industrial units as well as derivative egg industrial units in order to optimize this technology and be able to implement it in an industrial scale.
  
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  One of the main advantages of this technology is using an industrial residue avoiding its deposition. Yearly, in Portugal, the production of eggshell waste is about 2600 tones which mean a cost about 122 Euros/ton for transport and treatment. The economical interest for an industrial unit that produces eggshell derivates is very relevant. For a ceramic unit there is the chance to enlarge the possibility of using a calcium residue substituting calcite, the traditional raw material, more expensive, without affecting final ceramic properties. Read more
O-1120IK4 - IKERLAN / Spain 653

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Customized Microfluidic Stations

microfluidic devices, microfluidics, lab-on-a-chip, Cell culturing
- Description of the technology offer :
  
  Customized microfluidic stations, including pumps, valves, flow sensors, heating/cooling units and compact macro-to-micro connections of various types (electrical, pneumatic, fluidic, optical) to actuate/feed microfluidic devices.
  
  The stations are highly integrated and provide a flexible and versatile testbed for research purposes. The desired components can be chosen to configure the unit, which can be controlled via PC using the included software. An exchangeable packaging adapts the format of the microfluidic device to the station and provides plug and play connectivity to this as well as effortless replacement of devices.
  
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  High integration of actuation and feeding sources with effortless, leaktight connectivity to any microfluidic device format. Centrallized control via PC. The use of an exchangeable packaging allows adaptability and easy replacement, without having to re-tune the system.
  
  Consultancy Service available, to help you design and fabricate your devices, from a few units to a few thousands. Patented technology with integrated fluidic control in monolithic, polymeric devices. Read more
O-1168DYNATABS, LLC / United States 921

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Naturally superior oral edible strips, and therapeutic pre-moistened face masks for good health on the go

supplements, pills, health, wellness, Oral edible strips, healthy ingredients, ingredients, OTC, vitamins, stress support, green tea, diet
- Description of the technology offer :
  
  Naturally superior oral edible strips, and therapeutic pre-moistened face masks for good health on the go especially for the 40% of the population unable to swallow pills, and want proper aging management. Products sold globally.
  
  DYNATABS® line features varieties of innovative products that are formulated in a variety of tropical and traditional great tasting flavors that dissolve quickly on the tongue so you do not need any water. The rapid delivery of nutritional components from a product small enough to fit in your pocket or purse offers convenient transportability of a supplement that has never been available before, maintaining nutritional compliance.
  
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  The Surest Way to get Stronger Sales is to Sell a Stronger Product!
  DYNATABS® is a U.S.A. company, that targets The health & wellness industry of the 40% of the population who cannot swallow pills which is an extremely large product demand niche worldwide.
  
  DYNATABS® perfected Oral Edible Strips increases bio-availability of nutritional herbal remedies that cannot be reproduced or achieved with common capsules or pills,and whose delivery with full efficacy can be achieved in moments by its dissolving on the tongue instantly delivering its full.
  
  Healthy ingredients with a blast of delightful tropical flavor directly into the blood stream, completely bypassing the diluting less absorbing digestive track working with your own body chemistry, without the choking hazzards of bulky pills and capsules or bitter taste often found from liquids Read more
O-1243University of Burgos / Spain 92

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Demetalization of sewage sludges through physico-chemical processes

sewage sludge, demetalization, organic fertilizer, heavy metals.
- Description of the technology offer :
  
  The agronomic use of sewage sludge has as main constrain the presence of high content of heavy metals. The proposed process optimizes their dissolution by a suitable combination of acid and complexing agents as extractant and thereafter the recovery of metal-enriched fractions using membrane separation and cation exchange techniques.
  
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  Different processes have been effectively used for the demetallization of sewage sludge: chemical extraction, bioleaching, electrokinetic processes and supercritical fluid extraction. Of all these, is the chemical extraction which achieved the most promising results of implementation, although due to the high variability in the origin and state of sludges, the high treatment volume and the associated cost, is essential to achieve the maximum metal recovery with the minimum operating cost, which is achieved by optimizing the extractive agent and an appropriate combination of membrane separation processes and cation exchange resins. Read more

Featured innovation provider University of Dundee

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O-1247University of Burgos / Spain 739

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Large scale structural testing for civil engineering, energy industry and others, including static and dynamic testings.

Ensayos a gran escala, ensayos dinámicos, fatige / Large Scale testing, dynamic testing, fatigue...
- Description of the technology offer :
  
  Large scale structural testing can be developed in our laboratory. The main field is civil engineering, but others industrial sectors can be held, as energy industry, aerospace, automotive industry, etc.
  Static and or dynamic testing can be carried out, including large cyclic testings, seismic testing, etc.
  Our services include testing design (both conceptual and detailed design), FEM models development, results analysis, improve proposal of the initial design provided by customer, etc.
  
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  The integration of numerical simulation technologies and testing capacities, improved designs can be obtained, making them optimal for their intended use.
  Using a own protocol, it is possible to test 1:1 scale parts of a structure.
  Through the development of finite element models of the testings, it is possible to compare the failure modes of the testing specimens with the ones of the complete structure. Using the safety factors obtained in the test, it is possible to accurately determine the real safety factor of the whole structure. Read more
O-1250UATEC - Technology Transfer Office of University of Aveiro / Portugal 94

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New Bioreactor for tissue engineering

tissue, tissues, Bioengineering, tissue engineering, cellular structures, cell culture devices, bioreactor, laboratory equipment
- Description of the technology offer :
  
  A group of researchers from a Portuguese University has developed a new bioreactor for tissue engineering. The proposed device allows not only for cell growth but also a deep biochemical and biomechanical characterization of both two-dimensional and tree-dimensional constructs and in real time, without interrupting the cellular growth. The modes and types of stimulation are modified independently by the bioreactor according to the biomechanical and biochemical properties of cellular structures by one or more objective functions previously defined in the control system. The university is looking for industrial partners interested for joint development and/or licensing agreement for production and commercialization of the device
  
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  When compared to other solutions, this system as the following advantages:
  It allows to establish a correlation between a multiplicity of mechanical properties and also biochemical properties
  •It is highly flexible in the sense that it can be used with different cell types
  •It can be used using different cell culture devices
  •It may present up to 3 simultaneous movements with only one actuator
  •It has a specific software that allows the control the diferent mechanical parameters
  •It allows for comparison of static and dynamic cultures
  •It allows the combination of several diferente experimente set-ups
  •It allows the adaptation of type and mode of mechanical stimuli in relation to the other bioreactor parameters or in fucntion of the biochemical and biomechanical characteristics of the 2D or 3D construct in real time which allows an improvement of its properties Read more
O-1245Sensors, Romote Sensing and Infrared Image Laboratory / Spain 79

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New Techniques for Elucidation of Thermodynamic Parameters

polymers, thermography, thermodynamic, thermodynamics, Thermal material testing, Thermal insulation
- Description of the technology offer :
  
  INFRARED LAB and the Spectral Sensors Laboratory (LIR/LSE) of the Carlos III University of Madrid have developed techniques of Elucidation of Thermodynamic Parameters.
  Knowledge of the thermodynamic properties of a material and its application to models of classical heat transfer, allows the prediction of the behaviour of the materials in any environment against any stimulus.
  
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  New materials are revolting important sectors such aeronautics and construction, whose ramifications reach many other areas.
  
  Knowledge of the thermal parameters is a key aspect in the development and improvement of these new materials. INFRARED LAB-LIR has IR thermography techniques for the empirical determination of thermodynamic parameters and capability to create validation models due the laboratory infrastructure (which includes excitation systems and image in the infrared and modeling software). Read more
O-1240Gaiker, Technological Centre / Spain 87

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New experimental toolbox to cover the preclinical safety and efficacy evaluation of topical products based on human skin explants.

personal care, cosmetics, cosmetic, dermatology, skin, skin explants, topical products
- Description of the technology offer :
  
  Skin absorption, penetration, efficacy and safety testing using healthy or damaged -atopic dermatitis, psoriaris, cutaneous photo-ageing, diabetic - human skin explants for topical active principles or final formulations.
  
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  The use of human skin explants have great advantages compared to monolayer cell cultures (1) they maintain a tridimensional structure and cell type differentiation balanced (2) they are stable up to 14 days in culture (3) they allow to test different type of vehicles in the final formulation.
  
  Regarding cosmetic products, with the coming into force of the new Cosmetics Regulation (No 1223/2009) this year, the use of animal experimentation is banned for any ingredient imported or developed in the EU. In this sense it is imperative that the in vitro alternatives used readily resemble their in vivo counterparts. The experimental toolbox based on human skin explants presented herein represents an alternative methodology which supports current EU regulation. Read more

Featured innovation provider University of Cadiz

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O-1130Pointjust s.l. / Spain 799

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Novel cooking control technology, based on knowing how the temperature is distributed within food during its cooking, and predicts its evolution.

Food, technology, cooking, grilling, control, Happcc, meat, fish, steack, perfect, cook, grill
- Description of the technology offer :
  
  Do the perfect steak, and repeat it whenever you want. Point Just is a response to questions every cook faces when seeking the perfect steak. It adjusts the process to the characteristics of the particular piece of food and its performance while cooking.
  
  We have developed a hand fitted device, using low-cost electronics, temperature control (thermocouples), distance measurement, and computer literacy, the value is added by our knowledge of cooking processes, with which we will guide the cook to prepare his perfect steak. Our technology obtains information from inside the food during cooking, it analyses it in real time and anticipates its development, both in the heat-receiving surface (which will define its outer finish), and the interior of the food (which will define its cooking point).
  
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  What is the appropriate amount of heat? How is the heat transmitted inside the steak? When should I turn it over and when do I have to remove it from the heat? How does the initial temperature of the steak affect its cooking? What influence does the type of product have on how it’s cooked? Why is meat different from fish? How does thickness influence cooking?
  
  The cooking of the food is the last step in its preparation and determines the quality of the final product. If the result of the cooking is not what is expected, the diner will reject it, because the steak is too rare or overcooked.
  
  Until now, too much attention has been paid to the heat. This is one of the factors that affect cooking performance, but not the only one. The type of food, the thickness of the food, its initial temperature, or how it receives and transmits the heat internally, are also decisive in the end result of the cooking.
  
  Our technology is based on knowing how the temperature is distributed within the steak during its cooking, and predicts its evolution. On this basis, our software manages the cooking process to get your perfect steak.
  
  We have develop a hand fitted device, using low-cost electronics, temperature control (thermocouples), distance measurement, and computer literacy, the value is added by our knowledge of cooking processes, with which we will guide the cook to prepare his perfect steak.
  
  Our technology obtains information from inside the food during cooking, it analyses it in real time and anticipates its development, both in the heat-receiving surface (which will define its outer finish), and the interior of the food (which will define its cooking point).
  
  Based on this, it sends simple instructions to the cook (Increase heat, reduce heat, turn me over, remove me from the heat), to adjust the cooking to the characteristics and performance of the particular piece of food, guiding the cook to his aim. Read more
O-1192European University of Madrid / Spain 774

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ICT system to get an early diagnosis about skin cancer for children

Diagnosis, health systems, cancer, Skin Cancer, skin, dermatology, Telemedicine
- Description of the technology offer :
  
  This system will provide more information than current technologies through its capacity to recognize automatically the spectral signature of an injury. The evolution to a more complete diagnosis in real time, could try to eliminate biopsia and clinical analysis phases, improving quality of life in patients and saving time and money to health systems.
  
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  The welfare of people is presented as one of the greatest challenges for our society. In this research fit many projects related to all areas in a holistic place the individual at the heart of the innovation process. Its attention and care must be priority technologies and therefore will be placed at the service of those goals. There are many areas in which research in Information and Communication Technologies are particularly relevant and provide a huge value. The exponential increase of users of any health system, the continuous advances in management of human resources and material ones, accuracy in processes or analysis of information stored, are just some of the areas in which research ads value raised to those who develop it.
  
  Early detection of skin cancer save thousands of lives a year, with a higher incidence in disadvantaged having no cost.
  
  Progress in research on early detection of cancer in years ahead encryption to have a consolidated study shows.
  
  Positioned to project developers in the social forefront in helping cancer.
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O-1140University of Alicante / Spain 1715

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Novel photobioreactor for mass cultivation of microalgae

biomass, cosmetics, pharmaceuticals, food supplements, aquaculture, biofuels, microalgae, photobioreactor
- Description of the technology offer :
  
  The research group Polymer processing and pyrolysis of the University of Alicante has developed a novel photobioreactor to grow massively different species of microalgae on industrial scale with automation. The main advantages are: high productivity, better CO2 consumption, better light transfer to the culture, more effective shaking and less cleaning and maintenance time. It can be used in biofuels, aquaculture, food, pharmaceuticals, cosmetics, etc. The research group is looking for companies acquiring this technology for licensing agreement.
  
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  The main innovation of this invention is:
  
  • This novel photobioreactor combines the mechanism of a bubble column with the air-lift type for higher biomass production than that obtained for both systems separately.
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O-1230University Pablo de Olavide / Spain 311

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Composition for the treatment or prevention of diabetes

beta cells, pancreatic islets, pharmaceuticals, Healthcare, clinical, Biomedicine, diabetes
- Description of the technology offer :
  
  The present invention refers to a composition comprising a growth factor and an inhibiting agent, which can be used in the preparation of a drug that could be used for the treatment or prevention of diabetes mellitus. Thus, the present invention offers a response to the problem of loss of functionality and/or mass of the pancreatic beta cells in diabetes mellitus.
  
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  The compositions in the present invention can be formulated for their administration to animals and, preferably, to mammals, including humans, in a variety of ways already known in the state of the art.
  
  Without limitations, the compositions in the present invention can be part of aqueous or nonaqueous solutions, emulsions or suspensions and, alternatively, can be prepared for their administration as solids. Read more

Featured innovation provider IK4-IKERLAN

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O-1233University of Burgos / Spain 1337

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Advanced treatment process and biogas production from wastewater with high oil and grease content

Food processing wastewater, biological treatment, anaerobic membrane bioreactors (AnMBR), biogas.
- Description of the technology offer :
  
  Researchers at the University of Burgos have developed a process for the anaerobic treatment and biogas production from wastewater with high oil and grease content.
  It is known that even low levels of oil and grease produce important upsets of the conventional anaerobic treatment process in long term operation. In the same way, in the MBR technology it is recommended pre-degreasing oily wastewater to avoid fouling problems. However, the anaerobic treatment with membrane biomass retention and the application of advanced fouling control methods let recover the methanogenic potential of lipids making it a robust and competitive treatment method for wastewater with high oil and grease content.
  
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  Direct treatment of wastewater with high oil and grease content without pre-degreasing. Chemicals costs and sludge production are reduced by doing without the coagulation-flocculation-flotation processes. Oils and grease, according to their chemical composition, have a high methane potential that this process allows to recover. Read more
O-1234University of Burgos / Spain 1148

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New Ru(II) Arene Complexes with Potential Anticancer Activity.

ruthenium, Anticancer activity, cytotoxic, N-donor ligands and P-donor ligands
- Description of the technology offer :
  
  Our Research group (RUCA) in the University of Burgos, is focused on the design and characterization of new Ru(II) Arene complexes with N-donor and P-donor ligands with general formulae [RuX2(arene)(L)] y [RuX(arene)(L-L)]Y, where L = ligands belonging to the families of aryl-benzoazoles, bipyridines, aryl-triazines, and amino-phosphines. Such complexes have pharmacological interest in the treatment of different types of cancer diseases.
  
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  These complexes show a great deal of interest due to their potential anticancer activity in cisplatin-resistant tumours, and also because of their lower general toxicity, which would allow to reduce secondary effects. Read more
O-917CIBER-BBN / Spain 1966

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New Osteogenic Biomimetic Peptide

peptide, Osteogenic, bone, Regeneration, Disease, lesion, tissue, Implant, prothesis
- Description of the technology offer :
  
  The present invention comprises a peptide with osteogenic capacity, the sequence of nucleotides codifying for this peptide, as well as a genetic construction containing said sequence, a vector containing said construction or sequence, and a host cell containing this vector. The invention also comprises the use of the peptide, or its pharmaceutical compositions, for bone regeneration or coating of implants and prostheses.
  
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  The peptide consists of a region capable of binding to collagen type I, and a domain allowing the anchorage of osteoblasts, therefore stimulating bone formation where it is located. The peptide of the invention can act by itself or linked to a collagen matrix. Therefore, aspects of the invention refer to the following compositions: matrix of type I collagen comprising the peptide of the invention, matrix of type I collagen comprising the peptide and a bone morphogenetic protein (BMP).
  
  Besides, the invention refers to the use of the peptide and these matrices as medicaments or for the elaboration of medicaments for the treatment or prevention of bone diseases or lesions. This peptide stimulates a cellular increase of osteoblast differentiation marker, alkaline phosphatase. When ectopically implanted in rats, a great production of bone tissue was observed.
  
  The peptide or the mentioned matrices can be used for the coating of implants or prostheses. Due to these coatings, prostheses and implants present the capacity of regenerating bone, and allow the localized application of the peptide or the matrix, minimizing dispersion and favoring a better effect when used. Read more
O-918CIBER-BBN / Spain 1277

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New Delivery of Substances to Senescent Cells

senescent cells, senescence studies, nanodevices, Drug delivery, Biomarkers, cosmetics, β-Gal, Beta-Galactosidase, diskeratosis, fibroblasts, senescent-associated diseases, nanoparticles
- Description of the technology offer :
  
  This invention refers to nanodevices for controlled and specific delivery of substances (drugs, bio-actives, markers, cosmetics) to senescent cells. The nanodevice comprises a carrier enclosing the cargo and allowing its liberation when targeted cells are reached, by means of the interaction with senescence-associated beta-galactosidase (SA-b-Gal). Therefore, it is useful for senescence studies, prevention and treatment of senescent-associated diseases. Besides others where β-Gal is specifically present or increased. The invention also comprises preparation procedures and uses of the nanodevice. The invention belongs to the pharmaceutical and cosmetic fields.
  
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  A first aspect of the invention refers to a nanodevice (25 to 150 nm diameter) for the controlled delivery of substances. The liberation of the cargo in the cells is activated by the presence of a senescence-associated enzyme.
  
  Other aspects of the invention are: preparation procedures of nanodevices; pharmaceutical compositions and medicaments comprising nanodevices; their use to treat or prevent diseases where b-galactosidase is over-expressed; the uses of these nanodevices for the detection and quantification of senescent cells, and for the manufacture of cosmetic compositions.
  The cargo can be a marker, a compound for re-activation of telomerase, a cytotoxic compound, or any mixture of them. These substances selectively delivered can prevent, eliminate/replace, detect or mark senescent cells.
  
  Inventors have shown the liberation of cargo in the presence of b-Gal: (a) in a aqueous solution; (b) intracellular delivery of cargo in cultures of a strain of S. cerevisiae expressing b-Gal, opposite to wild type used as control; (c) selective delivery of substances to senescent cells in human cell cultures, dermis fibroblasts from two patients with congenital diskeratosis related to sex (X-CD) versus control fibroblasts, H460 lung cancer cells expressing telomerase (no senescent cells), and primary human cells. Viability studies showed that nanodevices of the invention are not toxic for human cells.
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Featured innovation provider University of Almeria

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O-1229University Pablo de Olavide / Spain 314

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Control of gene expression by means of a transcription attenuator

biotech, Biotechnology, molecular biology, cell biology, genetics, genes, gene expression, Biomedicine, biopharmaceuticals, pharmaceuticals
- Description of the technology offer :
  
  This deals with a system making it possible to control, in bacteria and by means of acetylsalicylic acid, the induced expression of external genes having a function of interest. In addition to making it possible to establish the time of large‐scale production of the codified proteins by the genes of interest by adding aspirin, the attenuator incorporated by this invention can reduce the production of proteins to a minimum when it is not desired, thus avoiding their possible deleterious effects upon the cell.
  
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  The patent makes it possible to increase the expression capacity in genes for the large‐scale production of proteins of interest, in a single bacterial culture and for a long period of time, by using just aspirin.
  
  Furthermore, the invention makes it possible to maintain extremely low levels of production in the absence of aspirin, thanks to an "attenuator", avoiding a possible deleterious effect upon the host cell without compromising the original capacity for producing maximum levels of expression with aspirin. Read more
O-1226University of Burgos / Spain 296

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“GET USED TO”, a Web-based Interactive Multimedia Application to support Independent Living at home as well as the use of ICT, for youth and adults with Intellectual Disabilities

Youth and adults with intellectual disabilities, interactivity, multimedia, internet, ICT, e-Learning
- Description of the technology offer :
  
  “Get used to” is a web-based interactive multimedia application that is purposely designed to assist youth and adults with intellectual disabilities (ID) to gain independent living. Security and order related issues are trained. The programme meets accessibility standards (WCAG) and is very flexible, adaptable and motivating. Activities can be done in any computer with internet access in a classroom, at home, etc. Thanks to a database, teachers and parents can track the student performance
  
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  We believe that this application can be considered as a first step for people with ID entering the e-learning, which is a widespread type of education among other groups of people such as developmental disabled people, older people, etc, but so far not adapted to the abilities of young and adults with ID.
  
  Regardless of the applications working with Virtual Reality (much more expensive, less accessible due to a greater demand of technological resources and a greater complexity of design and use, and more limited in the number of users per session), “Get used to” is maybe the only interactive multimedia application that works with realistic iconography (not drawings) and therefore completely aimed to adults and young people with ID, who moreover often complain, rightly we think, about that child connotation that the few multimedia applications at their disposal for training in any field have. Read more
O-1217European University of Madrid/Universidad Carlos III / Spain 334

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Method for classifying vehicular traffic

Smart cities, vehicle, traffic
- Description of the technology offer :
  
  The invention relates to method enabling the classification of vehicular traffic along a road having one or more lanes. The method enables the determination of when a vehicle has passed by and the determination of the parameters of said vehicle such as the speed or type thereof, wherein said measurements are not affected by factors that could affect the sensors, such as temperature changes or interference from nearby sensors, among others.
  
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  Within the variety of techniques that you can use to count vehicles, employees most frequently are those using sensors located on the pavement. Can be cited as examples the Pneumatic hoses, inductive loops, piezoelectric sensors, sensors based on fiber optic cables etc.These systems present several disadvantages, including the difficulty that entails installation (as it is the case of the inductive loops that have to be installed under the pavement), the safety of personnel responsible for performing the installation or the need to interrupt the traffic for the installation in the case of the hoses, the piezoelectric sensors and fiber optic cables. One of its disadvantages is the deterioration suffered by these devices by the passage of vehicles.
  
  The effectiveness of these systems may also depend on characteristics of the via (several lanes) and adverse weather conditions.A first alternative that prevents the installation directly on the pathway or beneath the surface of the track is to make use of non-intrusive techniques. Non-intrusive techniques that you can use in the count of vehicles are very different between them are what make use of sensors of infrared (IR), magnetic sensors, acoustic sensors, video, radar, ultrasound, etc.While the technique based on the analysis of the images recorded in video provides a large amount of data (number, category and speed of vehicles) and is easy to implement, it has been found that there are many factors that affect the performance of these systems: stationary and moving shadows, direct sun, light-dark transitions, errors in the operation of the software etc. Relation to acoustic systems, these problems in the detection of vehicles at rest and in situations of high traffic density. The radar is also commonly used but presents the disadvantage of its high cost and require calibrations frequent, also expensive. There are also devices based on the use of two Ultrasonic sensors tuned to two different frequencies and are located in two separate high supports. Sensors detect the passage of vehicles and make a classification of these according to your profile.
  
  This device is designed to detect and classify vehicles entering garages and building entrances. Even though such devices are suitable for low speed conditions and well preset parameters at the time of the Assembly, are not suitable in situations in which the speed of the vehicles is high (expressways) since it is not possible to draw the profile of the vehicle with precision, the presence of disturbances due to temperature changes, influence of high levels of noise and interference between sensors next make it is not appropriate for this type so demanding application.The present invention provides a method that makes use of ultrasonic distance sensors in such a way that, although the sensors are affected by disturbances such as those mentioned, this method allows to discriminate when a vehicle has passed, quickly takes and some parameters that characterize its type. Read more
O-1232anonymous company / Denmark 292

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Feed supplement for US dairy cows : A US-patented method of preventing parturient hypocalcemia in animals and compositions used therein

dairy cows, health, transition
- Description of the technology offer :
  
  A US-patented method of preventing parturient hypocalcemia in animals and compositions used therein. A coated version of zeolite ensure high palatability to the dry cows in late pregnancy as good appetite is important around calving. In the gut the product inproves ration mineral balance by ion Exchange binding of calcium and phosphorus. A daily amount of the product is given either as a top dressing or incorporated into the dry cow ration.
  
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  Product effect is based on the ion exchange capacity of zeolite A which is a microcrystalline mineral generally used as a water softener in the laundry industry, food industry etc. In the dairy cow it activates calcium mobilization to the blood thereby ensuring normal blood calcium levels around calving. By ensuring normality it prevents Health problems related to subnormal blood calcium levels. It is a highly efficient alternative to products based on acidifying the ration and thereby the cow, the so-called DCAD reducing products. The present innovation does not have the disadvantages of the acidifying products. Read more

Featured innovation provider University of Lleida

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O-1236University of Burgos / Spain 1301

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Use of organic residues in biodisinfection soil processes for the biological control of plant pathogens

agriculture, intensive agriculture, organic agriculture, plants, plant pathogens, Biodisinfection, greenhouses, Horticulture, agricultural production, agronomy, biological control, fumigants, biofumigación, organic waste, phytopathogenic
- Description of the technology offer :
  
  Laboratory and field experiences done by the research group UBUCOMP show that it is possible to obtain biofumigant effect through the anaerobic decomposition of an adecuate mixture of organic wastes of agricultural origin.
  
  The ban of chemical fumigants, such as halogenated hydrocarbons, on intensive agricultural production, has led to a increasing interest in new methods of biological control of soil-borne plant pathogens. One of the most promising methodologies is the biodesinfección consisting in the introduction of organic residues into soil solarization processes, whose decomposition produces gases with fumigant effect and contributes to restore soil health for later crops.
  
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  The substitution of chemical fumigants such as methyl bromide and other halogenated hydrocarbons, has been done looking for alternative new products with a similar effect such as as metam sodium or dazomet, products whose hydrolysis produces volatile isothiocyanates, but all of them facing increasing legal restrictions due to their toxicological and environmental problems. Alternatively, different processes have been used as so-called biological biofumigación, in which plants residues of Brassicas also produce isothiocyanates in their decomposition due to their high glucosinolate content. The objective is to generalize these processes using local wastes generated in agricultural or agro-industrial activity optimizing their use as soil biodisinfectants. Read more
O-1235University of Burgos / Spain 1501

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Computed tomography, Non-contact Laser Scanning for large and small objects, 3D modelling and Plastic laser-sintering of archaeological and paleontological remains

CT-scan, digitalization, casting, archaeology, Palaeontology, restoration, museums, education
- Description of the technology offer :
  
  The University of Burgos has an industrial system for computed tomography (CT-scan) and two high-resolution 3D scanners for fast and accurate 3D scanning of surfaces both, of large and small objects. Also posses a sophisticated equipment for the rapid production of high resolution replicas by Laser Sintering of polyamide powder that can reproduce in one step external and internal parts, mechanisms, etc.. Polyamide casts are created from 3D digital models generated by none destructive techniques as the CT-scan, CAD or lasser scanner.
  
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  1.These analytical techniques are NON-DESTRUCTIVE.
  2.With the CT-scan we can visualize and study the inside of objects and some properties as porosity or density.
  3.The 3D digital models allows reconstruction of missing parts, to interact actively with the objects (very attractive for young people and general public) and can be used to quickly exchange accurate information between specialists.
  4.The 3D models is accurate and can be obtained quickly with a minimum handle of the original. High-resolution three-dimensional replicas can be produced from the designs that have been generated by other applications like CAD, the CT-scan or 3D surface scanner.
  5.Storage of very accurate structural and morphological information (essential for the objects of the Cultural Heritage)
  
  To view images you can see the attachment Read more

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Cutting-edge technologies browser

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antithrombotic, Anticoagulant, heart attacks, blood coagulation

Inmunoassay, strip test, Lateral Flow, Immunochromatography, Point-of-Care, Point-of-Test, fluoresce

Highly sensitive lateral flow strip tests as rapid, easy-to-use, low-cost and portable biodetection systems to be implemented as quantitative analytical tools in human and animal health, food safety and environmental quality .

desalination, solar termal, ejector, small scale, low tech desalination

Substrate, screening, Cell, Culture

packing, plasticizer, plastic films, plastic waste, plastics, Plastic, bioplastics, food packaging, pharmaceutical packaging, packing, nanoclay, citric pectin

microscope, optical microscope, microscopy, optical microscopy, microscopic techniques, microscopic images, biology

culture monitorization, cell viability, flow citometry, Microalgae lipid content

TI ADC, bandwidth mismatch, mixed-signal calibration, digital calibration

egg, eggs, eggshell waste, egg derivatives, ceramic, ceramics, waste, residues

microfluidic devices, microfluidics, lab-on-a-chip, Cell culturing

supplements, pills, health, wellness, Oral edible strips, healthy ingredients, ingredients, OTC, vitamins, stress support, green tea, diet

sewage sludge, demetalization, organic fertilizer, heavy metals.

Ensayos a gran escala, ensayos dinámicos, fatige / Large Scale testing, dynamic testing, fatigue...

tissue, tissues, Bioengineering, tissue engineering, cellular structures, cell culture devices, bioreactor, laboratory equipment

polymers, thermography, thermodynamic, thermodynamics, Thermal material testing, Thermal insulation

personal care, cosmetics, cosmetic, dermatology, skin, skin explants, topical products

Skin absorption, penetration, efficacy and safety testing using healthy or damaged -atopic dermatitis, psoriaris, cutaneous photo-ageing, diabetic - human skin explants for topical active principles or final formulations.

Food, technology, cooking, grilling, control, Happcc, meat, fish, steack, perfect, cook, grill

Diagnosis, health systems, cancer, Skin Cancer, skin, dermatology, Telemedicine

biomass, cosmetics, pharmaceuticals, food supplements, aquaculture, biofuels, microalgae, photobioreactor

The main innovation of this invention is: • This novel photobioreactor combines the mechanism of a bubble column with the air-lift type for higher biomass production than that obtained for both systems separately. Read more

beta cells, pancreatic islets, pharmaceuticals, Healthcare, clinical, Biomedicine, diabetes

Food processing wastewater, biological treatment, anaerobic membrane bioreactors (AnMBR), biogas.

ruthenium, Anticancer activity, cytotoxic, N-donor ligands and P-donor ligands

These complexes show a great deal of interest due to their potential anticancer activity in cisplatin-resistant tumours, and also because of their lower general toxicity, which would allow to reduce secondary effects. Read more

peptide, Osteogenic, bone, Regeneration, Disease, lesion, tissue, Implant, prothesis

senescent cells, senescence studies, nanodevices, Drug delivery, Biomarkers, cosmetics, β-Gal, Beta-Galactosidase, diskeratosis, fibroblasts, senescent-associated diseases, nanoparticles

biotech, Biotechnology, molecular biology, cell biology, genetics, genes, gene expression, Biomedicine, biopharmaceuticals, pharmaceuticals

Youth and adults with intellectual disabilities, interactivity, multimedia, internet, ICT, e-Learning

Smart cities, vehicle, traffic

dairy cows, health, transition

agriculture, intensive agriculture, organic agriculture, plants, plant pathogens, Biodisinfection, greenhouses, Horticulture, agricultural production, agronomy, biological control, fumigants, biofumigación, organic waste, phytopathogenic

CT-scan, digitalization, casting, archaeology, Palaeontology, restoration, museums, education

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The main innovation of this invention is:

• This novel photobioreactor combines the mechanism of a bubble column with the air-lift type for higher biomass production than that obtained for both systems separately.
Read more