Innovation in ADN : Open opportunities ...

O-801University Pablo de Olavide / Spain 1009

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Systems of heterologous expression for the functional analysis of metagenomic DNA libraries

metagenomic, genes, patent, clones, genome, bacteria, microorganisms, DNA, library
- Description of the technology offer :
  
  The invention "Systems of heterologous expression for the functional analysis of metagenomic DNA libraries" refers to a system facilitating the expression of metagenomic genes that do not express by themselves in bacteria hosting a metagenomic DNA library, thus maximising the detection of the functions that, formerly, remained unidentified.
  
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  New and innovative aspects
  
  This patent refers to an expression system offering the possibility of identifying genes of interest that do not express by themselves in the bacteria hosting the metagenomic DNA library, making it possible to detect the functions that they codify and that, otherwise, would remain silenced.
  
  The invention results in a bigger higher number of metagenomic clones evidencing a concreteshowing a particular function of interest for a given metagenomic DNA library.
  
  The potential of metagenomics (the field of microbiology aimed at obtaining sequences of the genomes in different microorganisms, bacteria in this case, comprising a community, by extracting and analysing their DNA in a global manner) is thus enhanced. Read more
O-1034Grupo de Transductores Químicos - GTQ IMB-CNM (CSIC) / Spain 632

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New electric and reusable readout device for (bio)microarrays

microarray platforms, DNA, Proteins, Antibodies, peptides, carbohydrates, cells, tissue, Genomics, proteomics, drug discovery, clinical diagnostics, POC Applications, archaeology, medicine, veterinary
- Description of the technology offer :
  
  Microarray platforms with different biological components (e.g. DNA, proteins, antibodies, peptides, carbohydrates, cells or tissue) are being developed and commercialized as powerful highthroughput analytical tools with application in genomics, proteomics, drug discovery, or clinical diagnostics. CSIC has patented an electric and reusable microarray reader that enables to work with standard low cost substrates of traditional fluorescent reading systems but with a much more compact and cost-effective equipment.
  
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  New and innovative aspects
  
  An alternative to optical readout devices and new POC Applications
  
  Unlike other electric readout systems, this reader can be cleaned manually or automatically and be reused an unlimited number of times.
  
  Compact, economic and reusable
  Electrical readout
  Device cost (Very Low)
  Substract cost (Very Low) Read more
O-457Laser Consult Ltd. / Hungary 1183

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Quinazolinone - derivatives and their use

Medical treatment, Healthcare, Pharmaceutical industry, Quinazolinone, PARP, PARP enzyme inhibitory
- Description of the technology offer :
  
  Our partner, a Hungarian University has developed the quinazolinone - derivatives and their use for preparation of pharmaceutical compositions having PARP enzyme inhibitory effect. The client is looking for a sales agreement, a license agreement or a R&D agreement opportunity.
  
  Abstract:
  
  The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula, that inhibit a DNA-repairing enzyme, poly (ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutical compositions for preventing or treating illnesses where PARP-inhibition yields a beneficial effect. In general formula (I); R1 stands for either hydrogen or a group of general formula (a); R2 stands for a) hydrogen or C1-6 alkyl group, if R1 is other than hydrogen, and b) if R1 is hydrogen, then R2 may be a group of general formula (b), (c) or (d). The subject of the present invention also embraces the preparation process of the compounds described above.
  
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  Innovation of the technology:
  
  A series of 4(3H)-quinazolinone derivatives were synthesized by alkylating the original cyclic compounds and by nitrile acylation of antranilic acid, which was followed by the closure of the quinazoline ring. 4-(3H)-quinazolinone derivatives containing S-ethyl sidechains substituted with tertiary amines on the carbon of position 2 proved to be the most effective PARP inhibitors among the synthesized and examined compounds. The effect of nitroxide or amino precursor forms was smaller than that of the tertiary amines, but similar to each other, nevertheless having free radical scavenger anility they might be favorable. Read more
O-1122IK4 - IKERLAN / Spain 688

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Portable thermocycler based on microchambers

NASBA, immunoqPCR, qPCR, molecular biology, Thermocycler, lab-on-a-chip, genetics, cell biology
- Description of the technology offer :
  
  Compact thermocycler for molecular biology reactions (qPCR, immunoqPCR, NASBA), particularly aimed at: 1) Adaptation of DNA/RNA based reactions to micro-environments and their optimization, 2) Researchers in the field of Lab-on-a-Chip devices, 3) Portable tool for routine QC analyses in environmental/industrial locations, with lower time and reagent consumption than traditional instruments, 4) Educational purposes
  
  The system consists of a housing containing a microheater, a 2-wavelength fluorescent readout unit and software to define the customized thermal cycling protocols. The reactions are carried out in sealed, monolithic microchambers (0.01ml in volume) made of injected thermoplastic material (COP).
  The robustness of the technology has been proven for immuno-qPCR, qPCR and NASBA.
  
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  New and innovative aspects
  
  - Small scale, portable and simple device with a focus on QC at industrial POC
  - Lower reagent consumption than traditional systems and lower time-to-result
  - Lower sample preparation requirements
  - Modular construction for flexible readout exchange or integration with other developments
  - Ideal for Lab on a Chip developments, saving costs in the optimization of reactions Read more

Innovation in ADN : Open opportunities ... | Offers

Innovation in ADN : Open opportunities ... | Offers

Request Information>> Share tech offer>> Systems of heterologous expression for the functional analysis of metagenomic DNA libraries

metagenomic, genes, patent, clones, genome, bacteria, microorganisms, DNA, library

Request Information>> Share tech offer>> New electric and reusable readout device for (bio)microarrays

microarray platforms, DNA, Proteins, Antibodies, peptides, carbohydrates, cells, tissue, Genomics, proteomics, drug discovery, clinical diagnostics, POC Applications, archaeology, medicine, veterinary

Request Information>> Share tech offer>> Quinazolinone - derivatives and their use

Medical treatment, Healthcare, Pharmaceutical industry, Quinazolinone, PARP, PARP enzyme inhibitory

Request Information>> Share tech offer>> Portable thermocycler based on microchambers

NASBA, immunoqPCR, qPCR, molecular biology, Thermocycler, lab-on-a-chip, genetics, cell biology

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Systems of heterologous expression for the functional analysis of metagenomic DNA libraries

Request Information>> Share tech offer>>
New electric and reusable readout device for (bio)microarrays

Request Information>> Share tech offer>>
Quinazolinone - derivatives and their use

Request Information>> Share tech offer>>
Portable thermocycler based on microchambers