Drug D&D: inhibitor of VEGF and c-myc by modulation of sp1 transcription factor
Description of the technology offer
New analogue of Mithramycin (MTM), selected from a family of compounds discovered by combinatorial biosynthesis of aureolic acid biosynthetic genes, whose Mechanism of Action (MoA) consist of selective binding to GC-rich DNA sequences, especifically to the site of union of the transcription factor sp1, which is itself overexpressed in many types of tumor cells and causes the overexpression of its regulated genes, mainly VEGF and c-myc.
New and innovative aspects
Cancer represents a major unmet medical need today, therefore many R&D resources are being deployed to find new drugs to treat the disease. Deregulation of transcription factor activity is an important event in the pathogenesis of cancer. Compounds able to block overactive transcription factors and modulate gene expression are very attractive therapeutic agents, since just one compound could address multiple drug targets, avoiding the complexity of combination therapy of sing... read more
Vendor Organization : EntreChem SL / Spain 
Organization type : Spin off, Start up
Type of tech offer : Technology
Current Development Status : Research or Experimental
Required business relationship : License agreement , Joint venture agreement , Technical cooperation - further development , Technical cooperation - testing of new applications
Sector : Biotechnology, Pharmaceutical, Healthcare, Chemical
Domains of Knowledge : Life sciences, Chemistry
Tags : drugs, cancer, oncology, kinase inhibitor, Ikkb, Ikk2, NF-kB, VEGF, c-myc, genetic engineering, chiral building blocks
| Posted on: 28/05/2010 | Deadline : 28/07/2012 | Active users : 1362 | Tech Offer ID : O-208 |
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